175716

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4868339..4868751 Replicon chromosome
Accession NZ_CP062721
Organism Escherichia coli O157:H7 strain Z1815

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag ILQ54_RS24480 Protein ID WP_000132630.1
Coordinates 4868410..4868751 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4868339..4868415 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ54_RS24470 4864966..4866435 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
ILQ54_RS24475 4866435..4868189 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- 4868339..4868415 - 77 NuclAT_14 - Antitoxin
- 4868339..4868415 - 77 NuclAT_14 - Antitoxin
- 4868339..4868415 - 77 NuclAT_14 - Antitoxin
- 4868339..4868415 - 77 NuclAT_14 - Antitoxin
- 4868339..4868415 - 77 NuclAT_15 - Antitoxin
- 4868339..4868415 - 77 NuclAT_15 - Antitoxin
- 4868339..4868415 - 77 NuclAT_15 - Antitoxin
- 4868339..4868415 - 77 NuclAT_15 - Antitoxin
ILQ54_RS24480 4868410..4868751 + 342 WP_000132630.1 endoribonuclease SymE Toxin
ILQ54_RS24485 4868798..4869961 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
ILQ54_RS24490 4870009..4870890 - 882 WP_001304007.1 DUF262 domain-containing protein -
ILQ54_RS24495 4870987..4871151 - 165 WP_000394274.1 DUF1127 domain-containing protein -
ILQ54_RS24500 4871316..4872728 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
ILQ54_RS24505 4872971..4873171 - 201 WP_001310455.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4860538..4881753 21215


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T175716 WP_000132630.1 NZ_CP062721:4868410-4868751 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T175716 NZ_CP082149:c126314-125964 [Enterobacter cloacae complex sp.]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 77 bp

>AT175716 NZ_CP062721:c4868415-4868339 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References