Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4520575..4521114 Replicon chromosome
Accession NZ_CP062721
Organism Escherichia coli O157:H7 strain Z1815

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag ILQ54_RS22905 Protein ID WP_001303998.1
Coordinates 4520854..4521114 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID C3TP07
Locus tag ILQ54_RS22900 Protein ID WP_000729705.1
Coordinates 4520575..4520835 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ54_RS22880 4516329..4517114 - 786 WP_000207556.1 putative lateral flagellar export/assembly protein LafU -
ILQ54_RS22885 4517086..4518798 + 1713 Protein_4480 flagellar biosynthesis protein FlhA -
ILQ54_RS22890 4518943..4519440 - 498 Protein_4481 REP-associated tyrosine transposase RayT -
ILQ54_RS22895 4519616..4520389 - 774 WP_000543891.1 C40 family peptidase -
ILQ54_RS22900 4520575..4520835 + 261 WP_000729705.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
ILQ54_RS22905 4520854..4521114 + 261 WP_001303998.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
ILQ54_RS22910 4521270..4522010 + 741 WP_001225679.1 murein L,D-transpeptidase -
ILQ54_RS22915 4521981..4522748 - 768 WP_001301698.1 class II glutamine amidotransferase -
ILQ54_RS22920 4522853..4523431 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-85)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10026.71 Da        Isoelectric Point: 10.3188

>T175714 WP_001303998.1 NZ_CP062721:4520854-4521114 [Escherichia coli O157:H7]
MNSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLRFERTGT
HAALFG

Download         Length: 261 bp

>T175714 NZ_CP082147:c4795670-4795359 [Enterobacter cloacae complex sp.]
ATGCTATTCATTGAAACGGATATTTTCACAGAAGACGTCAAAACGTTACTGGATGACGACGAATACCATAAGCTTCAGGT
TTTCCTGGTAACGCAACCTAATTATGGCGATCTGATTCAGAATACGGGGGGCCTGCGAAAGATTCGCTGGTTTTCTGGAA
GCAAGGGAAAGCGTGGTGGAGTAAGGGTTATTTATTTTCATCGTACGCGTGAGTTTGAAATTAGGTTGCTGCTCATTTAT
CGCAAAGGGATCAAAGATGACCTGTCCGCGAAGGAGAAAGCCATTCTGAAAAAGATGATAGAGAGGTGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9377.74 Da        Isoelectric Point: 5.0758

>AT175714 WP_000729705.1 NZ_CP062721:4520575-4520835 [Escherichia coli O157:H7]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGV

Download         Length: 261 bp

>AT175714 NZ_CP082147:c4795358-4795068 [Enterobacter cloacae complex sp.]
ATGGATAAGGCGCTGTTTGAGCGATTAACCCAAAGCATTGCGCAAATGAACGAAATTGCCGAGGGCCAACGCGAGCCGTC
GCGTACGTTTCAAATCGATGCGATGAAAATAAAAGAAATTCGGCAGGCGTCCGGGTTGTCGCAGAGTAAATTCGCGAACT
TAATCTCAGTCAGTGTTGATACGTTGCGTAACTGGGAACAAGGCAGACGCTCACCCACAGGCCCGGCCAAAGCGCTCTTG
CGCGCCATTGCTAACGACCCTCAACATGTCATCCCTGCGCTATCGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References