Detailed information of TA system TA175672

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3626469..3626694
• Replicon: chromosome
• Accession: NZ_CP062719
• Organism: Escherichia coli O157:H7 strain Z1816

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: ILQ55_RS18735
• Protein ID: WP_000813263.1
• Coordinates: 3626469..3626624 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	3626636..3626694 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ILQ55_RS18700	3621923..3622636	-	714	WP_000261909.1	helix-turn-helix domain-containing protein	-
ILQ55_RS18705	3622774..3622970	-	197	Protein_3661	TrmB family transcriptional regulator	-
ILQ55_RS18710	3623257..3624075	-	819	WP_000265265.1	CPBP family intramembrane metalloprotease	-
ILQ55_RS18715	3624227..3624598	-	372	WP_000090264.1	antitermination protein	-
ILQ55_RS18720	3624588..3624959	-	372	WP_032283490.1	RusA family crossover junction endodeoxyribonuclease	-
ILQ55_RS18725	3624972..3626021	-	1050	WP_206338758.1	DUF968 domain-containing protein	-
ILQ55_RS18730	3626023..3626301	-	279	WP_001341388.1	hypothetical protein	-
ILQ55_RS18735	3626469..3626624	-	156	WP_000813263.1	type I toxin-antitoxin system toxin HokD	Toxin
-	3626636..3626694	+	59	-	-	Antitoxin
ILQ55_RS18740	3627229..3628002	+	774	WP_000160654.1	alpha/beta hydrolase	-
ILQ55_RS18745	3628354..3628767	-	414	WP_001151233.1	DUF977 family protein	-
ILQ55_RS18750	3628783..3629553	-	771	WP_000450992.1	DUF1627 domain-containing protein	-
ILQ55_RS18755	3629575..3630321	-	747	WP_000788751.1	ATP-binding protein	-
ILQ55_RS18760	3630328..3631419	-	1092	WP_206338777.1	DNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T175672 WP_000813263.1 NZ_CP062719:c3626624-3626469 [Escherichia coli O157:H7]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T175672 NZ_CP082128:c59754-59338 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT175672 NZ_CP062719:3626636-3626694 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin