Detailed information of TA system TA175650

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-sokW/Ldr(toxin)
• Location: 283262..283483
• Replicon: chromosome
• Accession: NZ_CP062719
• Organism: Escherichia coli O157:H7 strain Z1816

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: ILQ55_RS01345
• Protein ID: WP_001295224.1
• Coordinates: 283376..283483 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	283262..283327 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ILQ55_RS01325	278702..279604	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
ILQ55_RS01330	279615..280598	+	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
ILQ55_RS01335	280595..281599	+	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
ILQ55_RS01340	281629..282900	-	1272	WP_001301684.1	amino acid permease	-
-	283262..283327	-	66	NuclAT_16	-	Antitoxin
-	283262..283327	-	66	NuclAT_16	-	Antitoxin
-	283262..283327	-	66	NuclAT_16	-	Antitoxin
-	283262..283327	-	66	NuclAT_16	-	Antitoxin
-	283262..283327	-	66	NuclAT_21	-	Antitoxin
-	283262..283327	-	66	NuclAT_21	-	Antitoxin
-	283262..283327	-	66	NuclAT_21	-	Antitoxin
-	283262..283327	-	66	NuclAT_21	-	Antitoxin
ILQ55_RS01345	283376..283483	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
ILQ55_RS01350	283570..285249	-	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
ILQ55_RS01355	285246..285437	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
ILQ55_RS01360	285434..287005	-	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
ILQ55_RS01365	287278..287466	+	189	WP_001063316.1	YhjR family protein	-
ILQ55_RS01370	287478..287675	+	198	WP_000279508.1	AAA family ATPase	-
ILQ55_RS01375	287694..288230	+	537	WP_001270903.1	cellulose synthase operon protein YhjQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T175650 WP_001295224.1 NZ_CP062719:283376-283483 [Escherichia coli O157:H7]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T175650 NZ_CP082127:c50893-50516 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCATTTGTCCCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAATGGTAAATAACATTACCCAGGGTAAGCATCCGGAGGCGCAACAATGA

Antitoxin

Nucleotide

• Length: 66 bp

>AT175650 NZ_CP062719:c283327-283262 [Escherichia coli O157:H7]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin