Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3613068..3613293 Replicon chromosome
Accession NZ_CP062717
Organism Escherichia coli O157:H7 strain Z1825

Toxin (Protein)


Gene name hokW Uniprot ID -
Locus tag ILQ56_RS18655 Protein ID WP_000813263.1
Coordinates 3613068..3613223 (-) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 3613235..3613293 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ56_RS18620 3608522..3609235 - 714 WP_000261909.1 helix-turn-helix domain-containing protein -
ILQ56_RS18625 3609373..3609569 - 197 Protein_3645 TrmB family transcriptional regulator -
ILQ56_RS18630 3609856..3610674 - 819 WP_000265265.1 CPBP family intramembrane metalloprotease -
ILQ56_RS18635 3610826..3611197 - 372 WP_000090264.1 antitermination protein -
ILQ56_RS18640 3611187..3611558 - 372 WP_001217436.1 RusA family crossover junction endodeoxyribonuclease -
ILQ56_RS18645 3611571..3612620 - 1050 WP_001265172.1 DUF968 domain-containing protein -
ILQ56_RS18650 3612622..3612900 - 279 WP_001341388.1 hypothetical protein -
ILQ56_RS18655 3613068..3613223 - 156 WP_000813263.1 type I toxin-antitoxin system toxin HokD Toxin
ILQ56_RS18660 3613828..3614601 + 774 WP_000160654.1 alpha/beta hydrolase -
ILQ56_RS18665 3614953..3615366 - 414 WP_001151233.1 DUF977 family protein -
ILQ56_RS18670 3615382..3616152 - 771 WP_000450992.1 DUF1627 domain-containing protein -
ILQ56_RS18675 3616174..3616920 - 747 WP_000788751.1 ATP-binding protein -
ILQ56_RS18680 3616927..3618018 - 1092 WP_001205823.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5722.86 Da        Isoelectric Point: 6.1531

>T175636 WP_000813263.1 NZ_CP062717:c3613223-3613068 [Escherichia coli O157:H7]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T175636 NZ_CP082120:2696061-2696168 [Escherichia coli]
ATGACGCTCGCGCAGTTTACCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 59 bp

>AT175636 NZ_CP062717:3613235-3613293 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References