Detailed information of TA system TA175600

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3590646..3590871
• Replicon: chromosome
• Accession: NZ_CP062715
• Organism: Escherichia coli O157:H7 strain Z1826

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: ILQ57_RS18475
• Protein ID: WP_000813263.1
• Coordinates: 3590646..3590801 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	3590813..3590871 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ILQ57_RS18440	3586100..3586813	-	714	WP_000261909.1	helix-turn-helix domain-containing protein	-
ILQ57_RS18445	3586951..3587147	-	197	Protein_3610	TrmB family transcriptional regulator	-
ILQ57_RS18450	3587434..3588252	-	819	WP_000265265.1	CPBP family intramembrane metalloprotease	-
ILQ57_RS18455	3588404..3588775	-	372	WP_000090264.1	antitermination protein	-
ILQ57_RS18460	3588765..3589136	-	372	WP_001217436.1	RusA family crossover junction endodeoxyribonuclease	-
ILQ57_RS18465	3589149..3590198	-	1050	WP_001265172.1	DUF968 domain-containing protein	-
ILQ57_RS18470	3590200..3590478	-	279	WP_001341388.1	hypothetical protein	-
ILQ57_RS18475	3590646..3590801	-	156	WP_000813263.1	type I toxin-antitoxin system toxin HokD	Toxin
-	3590813..3590871	+	59	-	-	Antitoxin
ILQ57_RS18480	3591406..3592179	+	774	WP_000160654.1	alpha/beta hydrolase	-
ILQ57_RS18485	3592531..3592944	-	414	WP_001151233.1	DUF977 family protein	-
ILQ57_RS18490	3592960..3593730	-	771	WP_000450992.1	DUF1627 domain-containing protein	-
ILQ57_RS18495	3593752..3594498	-	747	WP_000788751.1	ATP-binding protein	-
ILQ57_RS18500	3594505..3595596	-	1092	WP_001205823.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T175600 WP_000813263.1 NZ_CP062715:c3590801-3590646 [Escherichia coli O157:H7]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T175600 NZ_CP082037:c2740954-2739632 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin

Nucleotide

• Length: 59 bp

>AT175600 NZ_CP062715:3590813-3590871 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin