Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 3081473..3081944 | Replicon | chromosome |
| Accession | NZ_CP062715 | ||
| Organism | Escherichia coli O157:H7 strain Z1826 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | ILQ57_RS15670 | Protein ID | WP_001303511.1 |
| Coordinates | 3081666..3081944 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | ILQ57_RS15665 | Protein ID | WP_001302048.1 |
| Coordinates | 3081473..3081664 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ILQ57_RS15625 | 3076680..3077264 | - | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
| ILQ57_RS15630 | 3077321..3077716 | - | 396 | WP_001118159.1 | DUF977 family protein | - |
| ILQ57_RS15635 | 3077732..3078501 | - | 770 | Protein_3058 | DUF1627 domain-containing protein | - |
| ILQ57_RS15640 | 3078527..3079267 | - | 741 | WP_000788938.1 | ATP-binding protein | - |
| ILQ57_RS15645 | 3079274..3080236 | - | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| ILQ57_RS15650 | 3080259..3080684 | - | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
| ILQ57_RS15655 | 3080681..3080983 | - | 303 | WP_000172738.1 | transcriptional regulator | - |
| ILQ57_RS15660 | 3081081..3081452 | + | 372 | WP_001169686.1 | hypothetical protein | - |
| ILQ57_RS15665 | 3081473..3081664 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| ILQ57_RS15670 | 3081666..3081944 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| ILQ57_RS15675 | 3082297..3082596 | + | 300 | WP_001240334.1 | hypothetical protein | - |
| ILQ57_RS15680 | 3082668..3082886 | + | 219 | WP_001171930.1 | hypothetical protein | - |
| ILQ57_RS15685 | 3083455..3083643 | + | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| ILQ57_RS15690 | 3083640..3083831 | + | 192 | WP_001090200.1 | DUF1482 family protein | - |
| ILQ57_RS15695 | 3083924..3086395 | + | 2472 | WP_072612735.1 | exonuclease | - |
| ILQ57_RS15700 | 3086460..3086708 | + | 249 | WP_000113189.1 | excisionase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Prophage | - | nleA/espI | 3040409..3091951 | 51542 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T175598 WP_001303511.1 NZ_CP062715:3081666-3081944 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T175598 NZ_CP082037:874773-875180 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT175598 WP_001302048.1 NZ_CP062715:3081473-3081664 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT175598 NZ_CP082037:874526-874792 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|