Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4827756..4828168 Replicon chromosome
Accession NZ_CP062713
Organism Escherichia coli O157:H7 strain Z1830

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag ILQ58_RS24175 Protein ID WP_000132630.1
Coordinates 4827827..4828168 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4827756..4827832 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ58_RS24165 4824383..4825852 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
ILQ58_RS24170 4825852..4827606 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- 4827756..4827832 - 77 NuclAT_14 - Antitoxin
- 4827756..4827832 - 77 NuclAT_14 - Antitoxin
- 4827756..4827832 - 77 NuclAT_14 - Antitoxin
- 4827756..4827832 - 77 NuclAT_14 - Antitoxin
- 4827756..4827832 - 77 NuclAT_15 - Antitoxin
- 4827756..4827832 - 77 NuclAT_15 - Antitoxin
- 4827756..4827832 - 77 NuclAT_15 - Antitoxin
- 4827756..4827832 - 77 NuclAT_15 - Antitoxin
ILQ58_RS24175 4827827..4828168 + 342 WP_000132630.1 endoribonuclease SymE Toxin
ILQ58_RS24180 4828215..4829378 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
ILQ58_RS24185 4829426..4830307 - 882 WP_001304007.1 DUF262 domain-containing protein -
ILQ58_RS24190 4830404..4830568 - 165 WP_000394274.1 DUF1127 domain-containing protein -
ILQ58_RS24195 4830745..4832157 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
ILQ58_RS24200 4832400..4832600 - 201 WP_001310455.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4819955..4841188 21233


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(20-71)


Sequences


Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T175572 WP_000132630.1 NZ_CP062713:4827827-4828168 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T175572 NZ_CP082029:c5094186-5093269 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCATCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 77 bp

>AT175572 NZ_CP062713:c4827832-4827756 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0


Antitoxin

Download structure file

References