Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 3065054..3065525 | Replicon | chromosome |
| Accession | NZ_CP062713 | ||
| Organism | Escherichia coli O157:H7 strain Z1830 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | ILQ58_RS15565 | Protein ID | WP_001303511.1 |
| Coordinates | 3065247..3065525 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | ILQ58_RS15560 | Protein ID | WP_001302048.1 |
| Coordinates | 3065054..3065245 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ILQ58_RS15520 | 3060261..3060845 | - | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
| ILQ58_RS15525 | 3060902..3061297 | - | 396 | WP_001118159.1 | DUF977 family protein | - |
| ILQ58_RS15530 | 3061313..3062082 | - | 770 | Protein_3037 | DUF1627 domain-containing protein | - |
| ILQ58_RS15535 | 3062108..3062848 | - | 741 | WP_000788938.1 | ATP-binding protein | - |
| ILQ58_RS15540 | 3062855..3063817 | - | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| ILQ58_RS15545 | 3063840..3064265 | - | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
| ILQ58_RS15550 | 3064262..3064564 | - | 303 | WP_000172738.1 | transcriptional regulator | - |
| ILQ58_RS15555 | 3064662..3065033 | + | 372 | WP_001169686.1 | hypothetical protein | - |
| ILQ58_RS15560 | 3065054..3065245 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| ILQ58_RS15565 | 3065247..3065525 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| ILQ58_RS15570 | 3065878..3066177 | + | 300 | WP_001240334.1 | hypothetical protein | - |
| ILQ58_RS15575 | 3066249..3066467 | + | 219 | WP_001171930.1 | hypothetical protein | - |
| ILQ58_RS15580 | 3067036..3067224 | + | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| ILQ58_RS15585 | 3067221..3067412 | + | 192 | WP_001090200.1 | DUF1482 family protein | - |
| ILQ58_RS15590 | 3067505..3069976 | + | 2472 | WP_072612735.1 | exonuclease | - |
| ILQ58_RS15595 | 3070041..3070289 | + | 249 | WP_000113189.1 | excisionase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Prophage | - | nleA/espI | 3023815..3075532 | 51717 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T175562 WP_001303511.1 NZ_CP062713:3065247-3065525 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T175562 NZ_CP082029:788184-788627 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT175562 WP_001302048.1 NZ_CP062713:3065054-3065245 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT175562 NZ_CP082029:787957-788187 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|