Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4481323..4481862 Replicon chromosome
Accession NZ_CP062711
Organism Escherichia coli O157:H7 strain Z1831

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag ILQ59_RS22605 Protein ID WP_001303998.1
Coordinates 4481602..4481862 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID C3TP07
Locus tag ILQ59_RS22600 Protein ID WP_000729705.1
Coordinates 4481323..4481583 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ59_RS22580 4477077..4477862 - 786 WP_000207556.1 putative lateral flagellar export/assembly protein LafU -
ILQ59_RS22585 4477834..4479546 + 1713 Protein_4421 flagellar biosynthesis protein FlhA -
ILQ59_RS22590 4479691..4480188 - 498 Protein_4422 REP-associated tyrosine transposase RayT -
ILQ59_RS22595 4480364..4481137 - 774 WP_000543891.1 C40 family peptidase -
ILQ59_RS22600 4481323..4481583 + 261 WP_000729705.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
ILQ59_RS22605 4481602..4481862 + 261 WP_001303998.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
ILQ59_RS22610 4482018..4482758 + 741 WP_001225679.1 murein L,D-transpeptidase -
ILQ59_RS22615 4482729..4483496 - 768 WP_001301698.1 class II glutamine amidotransferase -
ILQ59_RS22620 4483601..4484179 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-85)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10026.71 Da        Isoelectric Point: 10.3188

>T175534 WP_001303998.1 NZ_CP062711:4481602-4481862 [Escherichia coli O157:H7]
MNSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLRFERTGT
HAALFG

Download         Length: 261 bp

>T175534 NZ_CP082020:134845-134994 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9377.74 Da        Isoelectric Point: 5.0758

>AT175534 WP_000729705.1 NZ_CP062711:4481323-4481583 [Escherichia coli O157:H7]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGV

Download         Length: 261 bp

>AT175534 NZ_CP082020:c134800-134741 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References