Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3371065..3371860 Replicon chromosome
Accession NZ_CP062711
Organism Escherichia coli O157:H7 strain Z1831

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag ILQ59_RS17330 Protein ID WP_000854914.1
Coordinates 3371065..3371439 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag ILQ59_RS17335 Protein ID WP_001280954.1
Coordinates 3371486..3371860 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ59_RS17290 3366069..3366560 - 492 WP_001301587.1 DUF1097 domain-containing protein -
ILQ59_RS17295 3366662..3367216 - 555 WP_001001917.1 molecular chaperone YcdY -
ILQ59_RS17300 3367240..3367977 - 738 WP_000283664.1 zinc-binding phosphatase -
ILQ59_RS17305 3368032..3368970 - 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
ILQ59_RS17315 3369441..3370283 - 843 WP_001280481.1 DUF4942 domain-containing protein -
ILQ59_RS17320 3370368..3370565 - 198 WP_000839282.1 DUF957 domain-containing protein -
ILQ59_RS17325 3370577..3371068 - 492 WP_000976853.1 hypothetical protein -
ILQ59_RS17330 3371065..3371439 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
ILQ59_RS17335 3371486..3371860 - 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ILQ59_RS17340 3372023..3372244 - 222 WP_001220314.1 DUF987 domain-containing protein -
ILQ59_RS17345 3372307..3372783 - 477 WP_001186738.1 RadC family protein -
ILQ59_RS17350 3372799..3373284 - 486 WP_000214398.1 antirestriction protein -
ILQ59_RS17355 3373375..3374193 - 819 WP_001234682.1 DUF945 domain-containing protein -
ILQ59_RS17360 3374533..3375603 - 1071 WP_000102669.1 patatin-like phospholipase family protein -
ILQ59_RS17365 3375600..3376505 - 906 WP_000203541.1 chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgB / csgD / csgE / csgF / csgG 3362451..3373284 10833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T175527 WP_000854914.1 NZ_CP062711:c3371439-3371065 [Escherichia coli O157:H7]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T175527 NZ_CP082019:c4833657-4833124 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT175527 WP_001280954.1 NZ_CP062711:c3371860-3371486 [Escherichia coli O157:H7]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT175527 NZ_CP082019:c4833934-4833668 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References