Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4763063..4763475 Replicon chromosome
Accession NZ_CP062702
Organism Escherichia coli O157:H7 strain Z1834

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag ILQ62_RS23655 Protein ID WP_000132630.1
Coordinates 4763134..4763475 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4763063..4763139 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ62_RS23645 4759690..4761159 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
ILQ62_RS23650 4761159..4762913 + 1755 WP_000110094.1 restriction endonuclease subunit S -
- 4763063..4763139 - 77 NuclAT_14 - Antitoxin
- 4763063..4763139 - 77 NuclAT_14 - Antitoxin
- 4763063..4763139 - 77 NuclAT_14 - Antitoxin
- 4763063..4763139 - 77 NuclAT_14 - Antitoxin
- 4763063..4763139 - 77 NuclAT_15 - Antitoxin
- 4763063..4763139 - 77 NuclAT_15 - Antitoxin
- 4763063..4763139 - 77 NuclAT_15 - Antitoxin
- 4763063..4763139 - 77 NuclAT_15 - Antitoxin
ILQ62_RS23655 4763134..4763475 + 342 WP_000132630.1 endoribonuclease SymE Toxin
ILQ62_RS23660 4763522..4764685 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
ILQ62_RS23665 4764733..4765614 - 882 WP_001304007.1 DUF262 domain-containing protein -
ILQ62_RS23670 4765711..4765875 - 165 WP_000394274.1 DUF1127 domain-containing protein -
ILQ62_RS23675 4766052..4767464 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
ILQ62_RS23680 4767707..4767907 - 201 WP_001310455.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4755262..4776489 21227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T175423 WP_000132630.1 NZ_CP062702:4763134-4763475 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T175423 NZ_CP081939:1486789-1486965 [Avibacterium paragallinarum]
GTGAACAGCAAACAAATGATAAAATTGCTCAAACAAGATGGTTGGTATCTTGACAGCATAAATGGAAGCCACCACCATTT
TGAGCATCATCAAAAAAAGGGAAAAGTTACCGTTCCCCACCCAAGAGCCGAATTAGGACATCTTGAAAAATTAATCAGAA
AACAAGCGGGGCTATAA

Antitoxin


Download         Length: 77 bp

>AT175423 NZ_CP062702:c4763139-4763063 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References