Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4415262..4415801 Replicon chromosome
Accession NZ_CP062702
Organism Escherichia coli O157:H7 strain Z1834

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag ILQ62_RS22080 Protein ID WP_001303998.1
Coordinates 4415541..4415801 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID C3TP07
Locus tag ILQ62_RS22075 Protein ID WP_000729705.1
Coordinates 4415262..4415522 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ62_RS22055 4411016..4411801 - 786 WP_000207556.1 putative lateral flagellar export/assembly protein LafU -
ILQ62_RS22060 4411773..4413485 + 1713 Protein_4321 flagellar biosynthesis protein FlhA -
ILQ62_RS22065 4413630..4414127 - 498 Protein_4322 REP-associated tyrosine transposase RayT -
ILQ62_RS22070 4414303..4415076 - 774 WP_000543891.1 C40 family peptidase -
ILQ62_RS22075 4415262..4415522 + 261 WP_000729705.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
ILQ62_RS22080 4415541..4415801 + 261 WP_001303998.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
ILQ62_RS22085 4415957..4416697 + 741 WP_001225679.1 murein L,D-transpeptidase -
ILQ62_RS22090 4416668..4417435 - 768 WP_001301698.1 class II glutamine amidotransferase -
ILQ62_RS22095 4417540..4418118 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-85)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10026.71 Da        Isoelectric Point: 10.3188

>T175421 WP_001303998.1 NZ_CP062702:4415541-4415801 [Escherichia coli O157:H7]
MNSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLRFERTGT
HAALFG

Download         Length: 261 bp

>T175421 NZ_CP081939:c1339421-1339227 [Avibacterium paragallinarum]
ATGGCGAAAGAATTTAAGCGCGATTTGGTACAACTAGCCAAAAAAGCACCGCACTTATTTGTTCATCCCCTTAAAAACAA
TTTGAAAGGTTATATGGATTGCCACATTCTCAATGATCTCGTGCTAATTTATAAAATTGAACAGCAATGCCTAAAATTAA
TTCGGCTAAATACACATTCAGAAGTTTTTGCATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9377.74 Da        Isoelectric Point: 5.0758

>AT175421 WP_000729705.1 NZ_CP062702:4415262-4415522 [Escherichia coli O157:H7]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGV

Download         Length: 261 bp

>AT175421 NZ_CP081939:c1339745-1339455 [Avibacterium paragallinarum]
ATGACGAACAATAATGCCGTGGTGAATTTTCGTTTACCACAACATTTAAAAACAGAAGCATTTGAAGTGATTGCCCAATA
TGGTCTTACCCCATCACAAGTATTTAATATGTTTTTAACTGAAATTGCTGCCACCAAAGCGATTCCTTTGAGTTTGAATT
ATTTACAACCTAATGCAAAAACTTTAGCGGCAATGAATGAAATTGAAAGTGGAACGGCTGAACGTCTTTCTCTTGATGAC
AAAACTGATCTTGCCACCTTATTGCAACAAATAGCAGAAGAGAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References