Detailed information of TA system TA175392

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-sokW/Ldr(toxin)
• Location: 278423..278644
• Replicon: chromosome
• Accession: NZ_CP062702
• Organism: Escherichia coli O157:H7 strain Z1834

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: ILQ62_RS01325
• Protein ID: WP_001295224.1
• Coordinates: 278537..278644 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	278423..278488 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ILQ62_RS01305	273863..274765	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
ILQ62_RS01310	274776..275759	+	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
ILQ62_RS01315	275756..276760	+	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
ILQ62_RS01320	276790..278061	-	1272	WP_001301684.1	amino acid permease	-
-	278423..278488	-	66	NuclAT_16	-	Antitoxin
-	278423..278488	-	66	NuclAT_16	-	Antitoxin
-	278423..278488	-	66	NuclAT_16	-	Antitoxin
-	278423..278488	-	66	NuclAT_16	-	Antitoxin
-	278423..278488	-	66	NuclAT_21	-	Antitoxin
-	278423..278488	-	66	NuclAT_21	-	Antitoxin
-	278423..278488	-	66	NuclAT_21	-	Antitoxin
-	278423..278488	-	66	NuclAT_21	-	Antitoxin
ILQ62_RS01325	278537..278644	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
ILQ62_RS01330	278731..280410	-	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
ILQ62_RS01335	280407..280598	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
ILQ62_RS01340	280595..282166	-	1572	WP_001204925.1	cellulose biosynthesis protein BcsE	-
ILQ62_RS01345	282439..282627	+	189	WP_001063316.1	YhjR family protein	-
ILQ62_RS01350	282639..282836	+	198	WP_000279508.1	AAA family ATPase	-
ILQ62_RS01355	282855..283391	+	537	WP_001270903.1	cellulose synthase operon protein YhjQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T175392 WP_001295224.1 NZ_CP062702:278537-278644 [Escherichia coli O157:H7]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T175392 NZ_CP081896:709847-710332 [Klebsiella pneumoniae]
ATGATCTTGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Nucleotide

• Length: 66 bp

>AT175392 NZ_CP062702:c278488-278423 [Escherichia coli O157:H7]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin