Detailed information of TA system TA175354

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 5486616..5487316
• Replicon: chromosome
• Accession: NZ_CP062699
• Organism: Pseudomonas taiwanensis strain WRS8

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: Q88F93
• Locus tag: ICN73_RS24475
• Protein ID: WP_010954960.1
• Coordinates: 5487020..5487316 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: I7AUJ7
• Locus tag: ICN73_RS24470
• Protein ID: WP_003254235.1
• Coordinates: 5486616..5487017 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ICN73_RS24450	5481750..5482571	-	822	WP_012051719.1	transporter substrate-binding domain-containing protein	-
ICN73_RS24455	5482647..5483576	-	930	WP_014755873.1	FAD-binding protein	-
ICN73_RS24460	5483577..5484326	-	750	WP_014755872.1	electron transfer flavoprotein subunit beta/FixA family protein	-
ICN73_RS24465	5484862..5486544	+	1683	WP_012051718.1	electron transfer flavoprotein-ubiquinone oxidoreductase	-
ICN73_RS24470	5486616..5487017	-	402	WP_003254235.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
ICN73_RS24475	5487020..5487316	-	297	WP_010954960.1	type II toxin-antitoxin system MqsR family toxin	Toxin
ICN73_RS24480	5487411..5488736	-	1326	WP_012051717.1	MFS transporter	-
ICN73_RS24485	5488809..5489288	-	480	WP_012051716.1	hypothetical protein	-
ICN73_RS24490	5489457..5489933	-	477	WP_012051715.1	sigma-70 family RNA polymerase sigma factor	-
ICN73_RS24495	5490055..5491680	-	1626	WP_017148195.1	twin-arginine translocation signal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (6-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (74-109)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11133.22 Da
• Isoelectric Point: 10.2271

>T175354 WP_010954960.1 NZ_CP062699:c5487316-5487020 [Pseudomonas taiwanensis]
MEKRMPHCPLERVKALAAARRIRPTGAALKGAKALGMDFPGMLEVITSLKRTDFYKSMTSHIDHRVWQDVYRPLTAIGYV
YLKLSVVDDVLIVSFKEL

Nucleotide

• Length: 297 bp

>T175354 NZ_CP081892:329605-329973 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATAGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14684.76 Da
• Isoelectric Point: 4.9531

>AT175354 WP_003254235.1 NZ_CP062699:c5487017-5486616 [Pseudomonas taiwanensis]
MRCPICGGSELAPDIQGMPYSYKGEMTVIPEVSGDYCSACGECVLSHDEAMRVSHLMTAFERQVNANVVDPSFIASIRRK
FDLDQREAGEIFGGGVNAFSRYENGKTTPPVALVKLLKLLDRHPELFEEVRTA

Nucleotide

• Length: 402 bp

>AT175354 NZ_CP081892:329387-329608 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: Q88F93

Antitoxin

• AlphaFold DB: I7AUJ7