Detailed information of TA system TA175328

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 1340394..1340578
• Replicon: chromosome
• Accession: NZ_CP062471
• Organism: Staphylococcus aureus strain MRSA - AMRF 3

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: ILP75_RS06740
• Protein ID: WP_000482647.1
• Coordinates: 1340471..1340578 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1340394..1340454 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ILP75_RS06725	1335845..1336012	-	168	Protein_1287	hypothetical protein	-
ILP75_RS06730	1336243..1337976	-	1734	WP_000486506.1	ABC transporter ATP-binding protein/permease	-
ILP75_RS06735	1338001..1339764	-	1764	WP_001064814.1	ABC transporter ATP-binding protein/permease	-
-	1340394..1340454	+	61	-	-	Antitoxin
ILP75_RS06740	1340471..1340578	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
ILP75_RS06745	1340712..1341098	-	387	WP_000779360.1	flippase GtxA	-
ILP75_RS06750	1341356..1342498	+	1143	WP_001837638.1	glycerate kinase	-
ILP75_RS06755	1342558..1343217	+	660	WP_000831301.1	membrane protein	-
ILP75_RS06760	1343399..1344610	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
ILP75_RS06765	1344733..1345206	-	474	WP_000456486.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T175328 WP_000482647.1 NZ_CP062471:c1340578-1340471 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T175328 NZ_CP081889:c4625933-4625649 [Klebsiella pneumoniae]
ATGACCTATGAACTGGCGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT175328 NZ_CP062471:1340394-1340454 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin