Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1315082..1315599 Replicon chromosome
Accession NZ_CP062471
Organism Staphylococcus aureus strain MRSA - AMRF 3

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag ILP75_RS06605 Protein ID WP_000113262.1
Coordinates 1315082..1315348 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag ILP75_RS06610 Protein ID WP_000584499.1
Coordinates 1315348..1315599 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILP75_RS06580 1310506..1311042 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
ILP75_RS06585 1311276..1312100 - 825 WP_194085854.1 formate/nitrite transporter family protein -
ILP75_RS06590 1312316..1312501 - 186 WP_000230293.1 hypothetical protein -
ILP75_RS06595 1312585..1313052 - 468 WP_000153344.1 SRPBCC domain-containing protein -
ILP75_RS06600 1313238..1314788 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
ILP75_RS06605 1315082..1315348 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
ILP75_RS06610 1315348..1315599 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ILP75_RS06615 1315764..1315865 - 102 WP_031867537.1 hypothetical protein -
ILP75_RS06620 1315872..1316471 - 600 WP_000162799.1 DsbA family protein -
ILP75_RS06625 1316490..1316852 - 363 WP_000819843.1 DUF4467 domain-containing protein -
ILP75_RS06630 1317107..1318357 + 1251 WP_001012219.1 FemA/FemB family glycyltransferase FmhA -
ILP75_RS06635 1318454..1319185 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
ILP75_RS06640 1319182..1319901 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T175327 WP_000113262.1 NZ_CP062471:c1315348-1315082 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T175327 NZ_CP081889:c4517052-4516519 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTCTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT175327 WP_000584499.1 NZ_CP062471:c1315599-1315348 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT175327 NZ_CP081889:c4517329-4517063 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References