Detailed information of TA system TA175320

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 772687..772867
• Replicon: chromosome
• Accession: NZ_CP062471
• Organism: Staphylococcus aureus strain MRSA - AMRF 3

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: ILP75_RS03675
• Protein ID: WP_001801861.1
• Coordinates: 772687..772782 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	772810..772867 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ILP75_RS03650	768741..769367	+	627	WP_000669025.1	hypothetical protein	-
ILP75_RS03655	769394..770137	+	744	WP_174840254.1	exotoxin	-
ILP75_RS03660	770164..770916	+	753	WP_000764922.1	staphylococcal enterotoxin type 27	-
ILP75_RS03665	771048..771605	-	558	WP_000864141.1	ImmA/IrrE family metallo-endopeptidase	-
ILP75_RS03670	771789..772235	-	447	WP_000747808.1	DUF1433 domain-containing protein	-
ILP75_RS03675	772687..772782	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	772810..772867	-	58	-	-	Antitoxin
ILP75_RS03680	773433..775130	-	1698	WP_000447924.1	hypothetical protein	-
ILP75_RS03685	775108..775962	-	855	WP_001069960.1	DNA adenine methylase	-
ILP75_RS03690	776001..777266	-	1266	WP_000072555.1	restriction endonuclease subunit S	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk	766182..794228	28046

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T175320 WP_001801861.1 NZ_CP062471:772687-772782 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T175320 NZ_CP081889:322114-322482 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACCGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT175320 NZ_CP062471:c772867-772810 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin