Detailed information of TA system TA175314

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1014292..1014630
• Replicon: chromosome
• Accession: NZ_CP062469
• Organism: Staphylococcus aureus strain MRSA - AMRF 4

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: ILP76_RS04965
• Protein ID: WP_072353918.1
• Coordinates: 1014292..1014468 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1014456..1014630 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ILP76_RS04945	1009460..1013241	+	3782	Protein_972	hypothetical protein	-
ILP76_RS04950	1013234..1013386	+	153	WP_001000058.1	hypothetical protein	-
ILP76_RS04955	1013432..1013719	+	288	WP_001262620.1	hypothetical protein	-
ILP76_RS04960	1013775..1014149	+	375	WP_000340977.1	hypothetical protein	-
ILP76_RS04965	1014292..1014468	+	177	WP_072353918.1	putative holin-like toxin	Toxin
-	1014456..1014630	-	175	-	-	Antitoxin
ILP76_RS04975	1014680..1014934	+	255	WP_000611512.1	phage holin	-
ILP76_RS04980	1014946..1015701	+	756	WP_000861038.1	CHAP domain-containing protein	-
ILP76_RS04985	1015892..1016383	+	492	WP_000920038.1	staphylokinase	-
ILP76_RS04990	1017034..1017369	+	336	Protein_981	SH3 domain-containing protein	-
ILP76_RS04995	1017880..1018230	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
ILP76_RS05000	1018283..1018543	-	261	WP_001791826.1	hypothetical protein	-
ILP76_RS05005	1018854..1019033	-	180	WP_000669791.1	hypothetical protein	-
ILP76_RS05010	1019355..1019605	-	251	Protein_985	sphingomyelin phosphodiesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / sak / scn	973158..1018230	45072

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.43 Da
• Isoelectric Point: 9.9479

>T175314 WP_072353918.1 NZ_CP062469:1014292-1014468 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T175314 NZ_CP081881:c4695085-4694711 [Escherichia coli]
ATGGCAAAAAGAACTGCGCTTTTTGATACCAATATCCTTATCGATTTGTTCAGCGGACGAATTGAGGCAAAACAGGCTCT
GGAGGCATGGCCCCTACAGAATGCGATTAGTCTGGTCACATGGATGGAGGTGCTGGTTGGCGCAAAAAAATATGATCAAG
AACATCGCACACGGATTGCAATGAGTGCGTTTAACGTTATTGGGATTTCGCAGGATATCGCGGAACGAAGCGTTGCTTTA
AGGCAGGAGTATAGAATGAAACTTCCAGATGCCATTATTCTGGCAACAGCACAGATTTATGGCTTTGAACTGGTAACGCG
AAATACGAGAGATTTTGCGGGAATAGCAGGTGTCGTCACACCCTATGAGCTGTAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT175314 NZ_CP062469:c1014630-1014456 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Antitoxin