Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 989476..989890 Replicon chromosome
Accession NZ_CP062469
Organism Staphylococcus aureus strain MRSA - AMRF 4

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ILP76_RS04795 Protein ID WP_001065046.1
Coordinates 989476..989727 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ILP76_RS04800 Protein ID WP_000028424.1
Coordinates 989717..989890 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILP76_RS04755 985133..986053 + 921 WP_000138475.1 recombinase RecT -
ILP76_RS04760 986134..986751 + 618 WP_072353921.1 MBL fold metallo-hydrolase -
ILP76_RS04765 986752..987222 + 471 WP_000934762.1 single-stranded DNA-binding protein -
ILP76_RS04770 987252..988145 + 894 WP_194085676.1 DnaD domain-containing protein -
ILP76_RS04775 988152..988370 + 219 WP_000338527.1 hypothetical protein -
ILP76_RS04780 988379..988834 + 456 WP_000401965.1 RusA family crossover junction endodeoxyribonuclease -
ILP76_RS04785 988847..989215 + 369 WP_000101270.1 hypothetical protein -
ILP76_RS04790 989219..989461 + 243 WP_000131381.1 phi PVL orf 51-like protein -
ILP76_RS04795 989476..989727 + 252 WP_001065046.1 DUF1024 family protein Toxin
ILP76_RS04800 989717..989890 + 174 WP_000028424.1 hypothetical protein Antitoxin
ILP76_RS04805 989916..990173 + 258 WP_000248921.1 hypothetical protein -
ILP76_RS04810 990174..990335 + 162 WP_000889682.1 hypothetical protein -
ILP76_RS04815 990350..990883 + 534 WP_001061838.1 dUTP diphosphatase -
ILP76_RS04820 990920..991165 + 246 WP_001282074.1 hypothetical protein -
ILP76_RS04825 991162..991368 + 207 WP_000195803.1 DUF1381 domain-containing protein -
ILP76_RS04830 991365..991751 + 387 WP_000592201.1 hypothetical protein -
ILP76_RS04835 991748..991897 + 150 WP_000595305.1 transcriptional activator RinB -
ILP76_RS04840 992056..992706 + 651 WP_001005262.1 hypothetical protein -
ILP76_RS04845 992706..992906 + 201 WP_000265041.1 DUF1514 family protein -
ILP76_RS04850 992929..993390 + 462 WP_072495574.1 hypothetical protein -
ILP76_RS04855 993505..993957 + 453 WP_000406191.1 nucleoside triphosphate pyrophosphohydrolase family protein -
ILP76_RS04860 993973..994317 + 345 WP_000817289.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - hlb / sak / scn 973158..1018230 45072


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9377.26 Da        Isoelectric Point: 3.7128

>T175313 WP_001065046.1 NZ_CP062469:989476-989727 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T175313 NZ_CP081881:c4381959-4381786 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGCGCATTCCTGGTCGGAATAACCTGGCCAATGAGTTTACCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT175313 WP_000028424.1 NZ_CP062469:989717-989890 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT175313 NZ_CP081881:c4382283-4381987 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACCGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References