Detailed information of TA system TA175307

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 841656..841918
• Replicon: chromosome
• Accession: NZ_CP062469
• Organism: Staphylococcus aureus strain MRSA - AMRF 4

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: ILP76_RS03995
• Protein ID: WP_001802298.1
• Coordinates: 841656..841760 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	841755..841918 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ILP76_RS03980	838453..839235	+	783	WP_000908185.1	ABC transporter ATP-binding protein	-
ILP76_RS03985	839303..840160	+	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
ILP76_RS03990	840818..840976	-	159	WP_001792784.1	hypothetical protein	-
ILP76_RS03995	841656..841760	+	105	WP_001802298.1	hypothetical protein	Toxin
-	841755..841918	-	164	-	-	Antitoxin
ILP76_RS04000	842193..843284	-	1092	WP_000495669.1	hypothetical protein	-
ILP76_RS04005	843550..844527	-	978	WP_000019733.1	CDF family zinc efflux transporter CzrB	-
ILP76_RS04010	844529..844849	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
ILP76_RS04015	845001..845666	+	666	WP_001024089.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T175307 WP_001802298.1 NZ_CP062469:841656-841760 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T175307 NZ_CP081881:c3614183-3613881 [Escherichia coli]
ATGGCTCAAAAGAATAATATAAGGAGTTTTCGTGATGCCTGGCTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTGTCCGGGAAATTACAGGAATATTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATATTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin

Nucleotide

• Length: 164 bp

>AT175307 NZ_CP062469:c841918-841755 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin