Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 559165..559349 Replicon chromosome
Accession NZ_CP062469
Organism Staphylococcus aureus strain MRSA - AMRF 4

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag ILP76_RS02530 Protein ID WP_000482647.1
Coordinates 559165..559272 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 559289..559349 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILP76_RS02505 554537..555010 + 474 WP_000456489.1 GyrI-like domain-containing protein -
ILP76_RS02510 555133..556344 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
ILP76_RS02515 556526..557185 - 660 WP_000831298.1 membrane protein -
ILP76_RS02520 557245..558387 - 1143 WP_001176863.1 glycerate kinase -
ILP76_RS02525 558645..559031 + 387 WP_000779347.1 flippase GtxA -
ILP76_RS02530 559165..559272 + 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
- 559289..559349 - 61 - - Antitoxin
ILP76_RS02535 559900..561663 + 1764 WP_001064816.1 ABC transporter ATP-binding protein/permease -
ILP76_RS02540 561688..563421 + 1734 WP_000486491.1 ABC transporter ATP-binding protein/permease -
ILP76_RS02545 563652..563819 + 168 WP_001792506.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T175305 WP_000482647.1 NZ_CP062469:559165-559272 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T175305 NZ_CP081881:c2754733-2754631 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 61 bp

>AT175305 NZ_CP062469:c559349-559289 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References