Detailed information of TA system TA175302

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 199433..199589
• Replicon: chromosome
• Accession: NZ_CP062469
• Organism: Staphylococcus aureus strain MRSA - AMRF 4

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: -
• Locus tag: ILP76_RS00860
• Protein ID: WP_099560939.1
• Coordinates: 199433..199528 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	199553..199589 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ILP76_RS00835	195597..197225	+	1629	WP_061642462.1	recombinase family protein	-
ILP76_RS00840	197730..198080	+	351	WP_061544230.1	hypothetical protein	-
ILP76_RS00845	198167..198478	+	312	WP_061544231.1	hypothetical protein	-
ILP76_RS00850	198493..198996	+	504	WP_037559702.1	DUF1643 domain-containing protein	-
ILP76_RS00855	199011..199232	+	222	WP_061544232.1	hypothetical protein	-
ILP76_RS00860	199433..199528	+	96	WP_099560939.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	199553..199589	-	37	-	-	Antitoxin
ILP76_RS00865	199898..200851	-	954	WP_194085652.1	restriction endonuclease subunit S	-
ILP76_RS00870	201090..202259	-	1170	Protein_173	IS256 family transposase	-
ILP76_RS00875	202461..204017	-	1557	WP_194085653.1	type I restriction-modification system subunit M	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	198167..208066	9899

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3503.15 Da
• Isoelectric Point: 7.9875

>T175302 WP_099560939.1 NZ_CP062469:199433-199528 [Staphylococcus aureus]
MADILVNIMTTAASGCIVALFSYWLRKRDDK

Nucleotide

• Length: 96 bp

>T175302 NZ_CP081881:c2147328-2147221 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 37 bp

>AT175302 NZ_CP062469:c199589-199553 [Staphylococcus aureus]
ATGCACCAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Antitoxin