Detailed information of TA system TA175294

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2188089..2188428
• Replicon: chromosome
• Accession: NZ_CP062467
• Organism: Staphylococcus aureus strain MRSA - AMRF 5

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: ILP77_RS11045
• Protein ID: WP_073391028.1
• Coordinates: 2188089..2188310 (+)
• Length: 74 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2188253..2188428 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ILP77_RS11025	2185871..2186023	+	153	WP_001000058.1	hypothetical protein	-
ILP77_RS11030	2186069..2186356	+	288	WP_001262620.1	hypothetical protein	-
ILP77_RS11035	2186412..2186786	+	375	WP_000340977.1	hypothetical protein	-
ILP77_RS11040	2187207..2187980	+	774	WP_000750407.1	staphylococcal enterotoxin type A	-
ILP77_RS11045	2188089..2188310	+	222	WP_073391028.1	putative holin-like toxin	Toxin
-	2188253..2188428	-	176	-	-	Antitoxin
ILP77_RS11055	2188477..2188779	+	303	WP_000992284.1	phage holin	-
ILP77_RS11060	2188790..2190244	+	1455	WP_000909197.1	N-acetylmuramoyl-L-alanine amidase	-
ILP77_RS11065	2190634..2191572	+	939	WP_000239544.1	Panton-Valentine bi-component leukocidin subunit S	-
ILP77_RS11070	2191568..2192551	+	984	WP_024937002.1	Panton-Valentine bi-component leukocidin subunit F	-
ILP77_RS11075	2192800..2192985	+	186	WP_000470336.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 74 a.a.
• Molecular weight: 8689.56 Da
• Isoelectric Point: 10.7294

>T175294 WP_073391028.1 NZ_CP062467:2188089-2188310 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKKITIANFGWFRWLNGY

Nucleotide

• Length: 222 bp

>T175294 NZ_CP081881:c679517-679053 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA

Antitoxin

Nucleotide

• Length: 176 bp

>AT175294 NZ_CP062467:c2188428-2188253 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATTTAGAAAAAGGGCAACATACGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAACCAAAGTTAGCGAT
GGTTATTTTTTTATTG

Structures

Antitoxin