Detailed information of TA system TA175293

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 2164393..2164816
• Replicon: chromosome
• Accession: NZ_CP062467
• Organism: Staphylococcus aureus strain MRSA - AMRF 5

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: ILP77_RS10890
• Protein ID: WP_001837494.1
• Coordinates: 2164393..2164644 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A0E0VQM8
• Locus tag: ILP77_RS10895
• Protein ID: WP_000028422.1
• Coordinates: 2164634..2164816 (+)
• Length: 61 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ILP77_RS10830	2159960..2160109	+	150	WP_001081076.1	hypothetical protein	-
ILP77_RS10835	2160102..2160383	-	282	WP_000414755.1	hypothetical protein	-
ILP77_RS10840	2160449..2161219	+	771	WP_000190254.1	conserved phage C-terminal domain-containing protein	-
ILP77_RS10845	2161229..2162009	+	781	Protein_2089	ATP-binding protein	-
ILP77_RS10850	2162003..2162161	+	159	WP_000256597.1	hypothetical protein	-
ILP77_RS10855	2162176..2162397	+	222	WP_001123695.1	DUF3269 family protein	-
ILP77_RS10860	2162407..2162811	+	405	WP_000049795.1	DUF1064 domain-containing protein	-
ILP77_RS10865	2162816..2163001	+	186	WP_001187245.1	DUF3113 family protein	-
ILP77_RS10870	2163002..2163358	+	357	WP_000029376.1	hypothetical protein	-
ILP77_RS10875	2163362..2163604	+	243	WP_000131386.1	phi PVL orf 51-like protein	-
ILP77_RS10880	2163669..2164118	+	450	WP_000982708.1	hypothetical protein	-
ILP77_RS10885	2164115..2164400	+	286	Protein_2097	hypothetical protein	-
ILP77_RS10890	2164393..2164644	+	252	WP_001837494.1	DUF1024 family protein	Toxin
ILP77_RS10895	2164634..2164816	+	183	WP_000028422.1	hypothetical protein	Antitoxin
ILP77_RS10900	2164809..2165351	+	543	WP_000185660.1	dUTP pyrophosphatase	-
ILP77_RS10905	2165388..2165633	+	246	WP_001282074.1	hypothetical protein	-
ILP77_RS10910	2165630..2165836	+	207	WP_000195803.1	DUF1381 domain-containing protein	-
ILP77_RS10915	2165833..2166220	+	388	Protein_2103	hypothetical protein	-
ILP77_RS10920	2166217..2166366	+	150	WP_000595265.1	transcriptional activator RinB	-
ILP77_RS10925	2166366..2166566	+	201	WP_000265042.1	DUF1514 family protein	-
ILP77_RS10930	2166676..2167011	+	336	WP_001818120.1	hypothetical protein	-
ILP77_RS10935	2167244..2167543	+	300	WP_000988336.1	HNH endonuclease	-
ILP77_RS10940	2167674..2168019	+	346	Protein_2108	hypothetical protein	-
ILP77_RS10945	2168016..2169677	+	1662	WP_000625088.1	terminase large subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2152477..2164816	12339

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1024 (1-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9350.20 Da
• Isoelectric Point: 3.9022

>T175293 WP_001837494.1 NZ_CP062467:2164393-2164644 [Staphylococcus aureus]
MDNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Nucleotide

• Length: 252 bp

>T175293 NZ_CP081881:352310-352585 [Escherichia coli]
ATGAGAACCCAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAATCTCCTGTTCCTCAAGG
GATTAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Protein

• Length: 61 a.a.
• Molecular weight: 6741.63 Da
• Isoelectric Point: 4.2658

>AT175293 WP_000028422.1 NZ_CP062467:2164634-2164816 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Nucleotide

• Length: 183 bp

>AT175293 NZ_CP081881:352582-352941 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACATTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTAAATACTTA
TATTATTGAAACGCTAAATGAGCGTTTGAATCATTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VQM8