Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1821096..1821276 Replicon chromosome
Accession NZ_CP062467
Organism Staphylococcus aureus strain MRSA - AMRF 5

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag ILP77_RS09130 Protein ID WP_001801861.1
Coordinates 1821181..1821276 (-) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1821096..1821153 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILP77_RS09115 1816697..1817962 + 1266 WP_000072555.1 restriction endonuclease subunit S -
ILP77_RS09120 1818001..1818855 + 855 WP_001069960.1 DNA adenine methylase -
ILP77_RS09125 1818833..1820530 + 1698 WP_000447924.1 hypothetical protein -
- 1821096..1821153 + 58 - - Antitoxin
ILP77_RS09130 1821181..1821276 - 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
ILP77_RS09135 1821728..1822174 + 447 WP_000747808.1 DUF1433 domain-containing protein -
ILP77_RS09140 1822358..1822915 + 558 WP_000864141.1 ImmA/IrrE family metallo-endopeptidase -
ILP77_RS09145 1823047..1823799 - 753 WP_000764922.1 staphylococcal enterotoxin type 27 -
ILP77_RS09150 1823826..1824569 - 744 WP_174840254.1 exotoxin -
ILP77_RS09155 1824596..1825222 - 627 WP_000669025.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk 1799735..1827781 28046


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T175291 WP_001801861.1 NZ_CP062467:c1821276-1821181 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T175291 NZ_CP081881:267718-267825 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 58 bp

>AT175291 NZ_CP062467:1821096-1821153 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References