Detailed information of TA system TA175285

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1534830..1535108
• Replicon: chromosome
• Accession: NZ_CP062467
• Organism: Staphylococcus aureus strain MRSA - AMRF 5

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: ILP77_RS07520
• Protein ID: WP_001802298.1
• Coordinates: 1534830..1534934 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1534930..1535108 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ILP77_RS07505	1531627..1532409	+	783	WP_000908182.1	ABC transporter ATP-binding protein	-
ILP77_RS07510	1532477..1533334	+	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
ILP77_RS07515	1533992..1534150	-	159	WP_001792784.1	hypothetical protein	-
ILP77_RS07520	1534830..1534934	+	105	WP_001802298.1	hypothetical protein	Toxin
-	1534930..1535108	-	179	-	-	Antitoxin
ILP77_RS07525	1535367..1536458	-	1092	WP_000495669.1	hypothetical protein	-
ILP77_RS07530	1536724..1537701	-	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
ILP77_RS07535	1537703..1538023	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
ILP77_RS07540	1538175..1538840	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (10-244)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T175285 WP_001802298.1 NZ_CP062467:1534830-1534934 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T175285 NZ_CP081872:2359621-2360361 [Bacillus toyonensis]
TTGACGATCTCTAACATTCGAATTGGCTTATTTATTTTAGCAATCGTTTTTGTAGTTCTTGTTTTCTTTTATTGGAGAAA
TGAAGAGTTATATGAAGAGAAAAAGCAGCGAATTCGAAAAACTTGGTATGGATTATTCATAACATCAGTCACAGTTTATT
TCATGATTAAAGGAATCGATTTAACCCTCTGGAAAAACTTATTAATGTTCACTGCGATGGTCATTTTTGTTGATATTTCA
TTTATTTTAACACCTAATATTTCCGAAATATGGGGAGCGAAATTTAGTGATATCGGTAAAACTGTTCAATCCATAAAGCG
GTCATTAATCGCTTCAAAAGCAAGAGGAGAAATATATACGAACATTATCCAAAATATTAATCCAGCAGCATTTGGGACGA
TGGAATGGCATACGGAAGAGGAATATACAAAAAGCTTAAACACATTTTTAGATTCATATGGGGAAAAAATTGGAGCGAAA
ATTGTTGTATTTGAAGCAGCGAATGAATTAAATACGGGCTTTCGTGGTATTCGTTCTCAATTTAGTATTACTATACCTAT
AGAGCATATAGAGCAATTGAATGAACAAAAAGCAGTGCAAGTAGAAAACGTGGGAATTATACCAGCAAAAATAATGAATG
ATGTTTTTATCGTGATTGATGGGAAGAAGAATAGCCTGCAGGATCGAGATTTTGAAAATGTATATAATTTAACGATACAT
CATAGTTATTTTAGTAAGTAG

Antitoxin

Nucleotide

• Length: 179 bp

>AT175285 NZ_CP062467:c1535108-1534930 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin