175283

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1277903..1278420 Replicon chromosome
Accession NZ_CP062467
Organism Staphylococcus aureus strain MRSA - AMRF 5

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag ILP77_RS06195 Protein ID WP_000113262.1
Coordinates 1278154..1278420 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag ILP77_RS06190 Protein ID WP_000584499.1
Coordinates 1277903..1278154 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILP77_RS06160 1273601..1274320 + 720 WP_000479576.1 amino acid ABC transporter permease -
ILP77_RS06165 1274317..1275048 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
ILP77_RS06170 1275145..1276395 - 1251 WP_001012219.1 FemA/FemB family glycyltransferase FmhA -
ILP77_RS06175 1276650..1277012 + 363 WP_000819843.1 DUF4467 domain-containing protein -
ILP77_RS06180 1277031..1277630 + 600 WP_000162799.1 DsbA family protein -
ILP77_RS06185 1277637..1277738 + 102 WP_031867537.1 hypothetical protein -
ILP77_RS06190 1277903..1278154 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ILP77_RS06195 1278154..1278420 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
ILP77_RS06200 1278714..1280264 + 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
ILP77_RS06205 1280450..1280917 + 468 WP_000153344.1 SRPBCC domain-containing protein -
ILP77_RS06210 1281001..1281186 + 186 WP_000230293.1 hypothetical protein -
ILP77_RS06215 1281402..1282226 + 825 WP_000594630.1 formate/nitrite transporter family protein -
ILP77_RS06220 1282460..1282996 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T175283 WP_000113262.1 NZ_CP062467:1278154-1278420 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T175283 NZ_CP081870:310087-310437 [Rossellomorea marisflavi]
TTGATTGTAAAGCGTGGTGACGTATATTTTGCAGACCTTTCTCCTGTTGTTGGGTCGGAACAAGGAGGCGTCCGGCCGGT
CCTTGTCATTCAAAACGATATAGGGAACAGGTTCAGTCCCACTGTTATTGTCGCTGCTATCACTGCTCAGATCCAAAAAG
CGAAGTTGCCTACCCATGTCGAAATTGATTCCAAACGGTACGGCTTTGAACGTGATTCCGTAATCTTGCTCGAACAGATC
AGGACCATCGATAAACAGCGTCTGACCGATAAGATCACACACCTGGACGACGAAATGATGGAAAAAGTCGATGACGCCCT
CCAGATTAGTGTTGGTCTCATACAATTTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT175283 WP_000584499.1 NZ_CP062467:1277903-1278154 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT175283 NZ_CP081870:309801-310082 [Rossellomorea marisflavi]
GTGTCTGAATCCAGCGCAACAACGGAAATTTTGATTCGTCTTCCGCAACAGCTCGTCACAGAACTGGACGGCTTTGCAGA
TCAGGAAAATGTGAATCGCAATGAGTTTATTTATCGTGCTACTAAAATGTATTTAAGAGAGCGTAAGAAACGACATCTGC
GTGAATCCATGAGACGAGGCTATATGGAAATGGCTAAGATCAATCTCGCCATCGCTTCGGAAGCAATCCAGGCAGAATAT
GAGGCAGAACATACAGTCGAACGCTTAGTAAGCGGAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References