Detailed information of TA system TA175281

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 1251598..1251782
• Replicon: chromosome
• Accession: NZ_CP062467
• Organism: Staphylococcus aureus strain MRSA - AMRF 5

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: ILP77_RS06055
• Protein ID: WP_000482647.1
• Coordinates: 1251598..1251705 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1251722..1251782 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ILP77_RS06030	1246970..1247443	+	474	WP_000456486.1	GyrI-like domain-containing protein	-
ILP77_RS06035	1247566..1248777	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
ILP77_RS06040	1248959..1249618	-	660	WP_000831301.1	membrane protein	-
ILP77_RS06045	1249678..1250820	-	1143	WP_001837638.1	glycerate kinase	-
ILP77_RS06050	1251078..1251464	+	387	WP_000779360.1	flippase GtxA	-
ILP77_RS06055	1251598..1251705	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	1251722..1251782	-	61	-	-	Antitoxin
ILP77_RS06060	1252412..1254175	+	1764	WP_001064814.1	ABC transporter ATP-binding protein/permease	-
ILP77_RS06065	1254200..1255933	+	1734	WP_000486506.1	ABC transporter ATP-binding protein/permease	-
ILP77_RS06070	1256164..1256331	+	168	Protein_1189	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T175281 WP_000482647.1 NZ_CP062467:1251598-1251705 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T175281 NZ_CP081866:16552-16968 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCGTCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTAGCCGGGACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCACGCCATCGCGGCGGGCGCCATCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT175281 NZ_CP062467:c1251782-1251722 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin