Detailed information of TA system TA175272

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 966666..967004
• Replicon: chromosome
• Accession: NZ_CP062465
• Organism: Staphylococcus aureus strain MRSA - AMRF 6

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: ILP78_RS04770
• Protein ID: WP_011447039.1
• Coordinates: 966666..966842 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	966830..967004 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ILP78_RS04750	961901..965686	+	3786	WP_000582165.1	hypothetical protein	-
ILP78_RS04755	965676..965828	+	153	WP_001153681.1	hypothetical protein	-
ILP78_RS04760	965875..966162	+	288	WP_001040261.1	hypothetical protein	-
ILP78_RS04765	966220..966516	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
ILP78_RS04770	966666..966842	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	966830..967004	-	175	-	-	Antitoxin
ILP78_RS04780	967054..967308	+	255	WP_000611512.1	phage holin	-
ILP78_RS04785	967320..968075	+	756	WP_000861038.1	CHAP domain-containing protein	-
ILP78_RS04790	968266..968757	+	492	WP_000919350.1	staphylokinase	-
ILP78_RS04795	969407..969742	+	336	Protein_942	SH3 domain-containing protein	-
ILP78_RS04800	969837..970286	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
ILP78_RS04805	970971..971321	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
ILP78_RS04810	971374..971634	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / sak / chp / scn	922772..971321	48549

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T175272 WP_011447039.1 NZ_CP062465:966666-966842 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T175272 NZ_CP081865:1452873-1453289 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATTATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACCGACATCCGGGTGGCGCTGCACCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGCCACGCCATCGCGGCGGGCGCCGTCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTGCCTGGACTGACACTGG
AAGACTGGGTTATTTAG

Antitoxin

Nucleotide

• Length: 175 bp

>AT175272 NZ_CP062465:c967004-966830 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin