Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 942958..943372 Replicon chromosome
Accession NZ_CP062465
Organism Staphylococcus aureus strain MRSA - AMRF 6

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ILP78_RS04605 Protein ID WP_001065046.1
Coordinates 942958..943209 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ILP78_RS04610 Protein ID WP_000028424.1
Coordinates 943199..943372 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILP78_RS04565 938615..939535 + 921 WP_084568172.1 recombinase RecT -
ILP78_RS04570 939616..940233 + 618 WP_078150688.1 MBL fold metallo-hydrolase -
ILP78_RS04575 940234..940704 + 471 WP_000934762.1 single-stranded DNA-binding protein -
ILP78_RS04580 940734..941627 + 894 WP_000148327.1 DnaD domain-containing protein -
ILP78_RS04585 941634..941852 + 219 WP_000338527.1 hypothetical protein -
ILP78_RS04590 941861..942316 + 456 WP_000401965.1 RusA family crossover junction endodeoxyribonuclease -
ILP78_RS04595 942329..942697 + 369 WP_000101270.1 hypothetical protein -
ILP78_RS04600 942701..942943 + 243 WP_000131381.1 phi PVL orf 51-like protein -
ILP78_RS04605 942958..943209 + 252 WP_001065046.1 DUF1024 family protein Toxin
ILP78_RS04610 943199..943372 + 174 WP_000028424.1 hypothetical protein Antitoxin
ILP78_RS04615 943398..943655 + 258 WP_000248921.1 hypothetical protein -
ILP78_RS04620 943656..943817 + 162 WP_000889682.1 hypothetical protein -
ILP78_RS04625 943832..944365 + 534 WP_001061838.1 dUTP diphosphatase -
ILP78_RS04630 944402..944647 + 246 WP_001282074.1 hypothetical protein -
ILP78_RS04635 944644..944850 + 207 WP_000195803.1 DUF1381 domain-containing protein -
ILP78_RS04640 944847..945233 + 387 WP_072426482.1 hypothetical protein -
ILP78_RS04645 945230..945379 + 150 WP_000595305.1 transcriptional activator RinB -
ILP78_RS04650 945538..946188 + 651 WP_001005262.1 hypothetical protein -
ILP78_RS04655 946188..946388 + 201 WP_000265041.1 DUF1514 family protein -
ILP78_RS04660 946416..946832 + 417 WP_000590122.1 hypothetical protein -
ILP78_RS04665 947065..947364 + 300 WP_000988336.1 HNH endonuclease -
ILP78_RS04670 947494..947839 + 346 Protein_917 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - hlb / sak / chp / scn 922772..971321 48549


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9377.26 Da        Isoelectric Point: 3.7128

>T175271 WP_001065046.1 NZ_CP062465:942958-943209 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T175271 NZ_CP081865:834783-835193 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT175271 WP_000028424.1 NZ_CP062465:943199-943372 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT175271 NZ_CP081865:834536-834802 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References