Detailed information of TA system TA175265

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 794293..794555
• Replicon: chromosome
• Accession: NZ_CP062465
• Organism: Staphylococcus aureus strain MRSA - AMRF 6

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: ILP78_RS03790
• Protein ID: WP_001802298.1
• Coordinates: 794293..794397 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	794392..794555 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ILP78_RS03775	791090..791872	+	783	WP_000908185.1	ABC transporter ATP-binding protein	-
ILP78_RS03780	791940..792797	+	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
ILP78_RS03785	793455..793613	-	159	WP_001792784.1	hypothetical protein	-
ILP78_RS03790	794293..794397	+	105	WP_001802298.1	hypothetical protein	Toxin
-	794392..794555	-	164	-	-	Antitoxin
ILP78_RS03795	794830..795921	-	1092	WP_000495669.1	hypothetical protein	-
ILP78_RS03800	796187..797164	-	978	WP_000019733.1	CDF family zinc efflux transporter CzrB	-
ILP78_RS03805	797166..797486	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
ILP78_RS03810	797638..798303	+	666	WP_001024089.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T175265 WP_001802298.1 NZ_CP062465:794293-794397 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T175265 NZ_CP081864:c2835374-2834946 [Symbiopectobacterium purcellii]
ATGCTGAAATATCTACTCGATACCAATATCTGTATTTACACCATCAAGAACAAACCACAGGAAGTCCGGGACGCTTTTTA
TCGTCATTACGGGCAGTTTGCTATCAGCGCTATCACGCTGATGGAACTGATCTATGGCGCGGAGAAATCGGTAAATCCAG
AAAAAAATCTGGCCGTGATAGAAGGGTTTTCTGCACGTCTGGAAGTGCAAACTTATGGCTTTGACGCTGCCGTACATACT
GGTCAAATTCGTGCGGAACTGGCAAAACAAGGAACACCCATTGGCCCGTATGATGCTATGTTAGCCGGTCACGCGCGGTC
CGCTGGTTTGATTCTGATAACGAACAATGTGCGTGAGTTTGAACGTGTGCCTGGATTACGTGTAGAAAACTGGGTCGGTA
GTTCGGCTGACAATAGCCAGCCTTTGTAA

Antitoxin

Nucleotide

• Length: 164 bp

>AT175265 NZ_CP062465:c794555-794392 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin