Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 513126..513310 Replicon chromosome
Accession NZ_CP062465
Organism Staphylococcus aureus strain MRSA - AMRF 6

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag ILP78_RS02330 Protein ID WP_000482647.1
Coordinates 513126..513233 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 513250..513310 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILP78_RS02305 508498..508971 + 474 WP_000456489.1 GyrI-like domain-containing protein -
ILP78_RS02310 509094..510305 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
ILP78_RS02315 510487..511146 - 660 WP_000831298.1 membrane protein -
ILP78_RS02320 511206..512348 - 1143 WP_001176863.1 glycerate kinase -
ILP78_RS02325 512606..512992 + 387 WP_000779347.1 flippase GtxA -
ILP78_RS02330 513126..513233 + 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
- 513250..513310 - 61 - - Antitoxin
ILP78_RS02335 513861..515624 + 1764 WP_001064816.1 ABC transporter ATP-binding protein/permease -
ILP78_RS02340 515649..517382 + 1734 WP_000486491.1 ABC transporter ATP-binding protein/permease -
ILP78_RS02345 517613..517780 + 168 WP_001792506.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T175263 WP_000482647.1 NZ_CP062465:513126-513233 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T175263 NZ_CP081864:c1201966-1201763 [Symbiopectobacterium purcellii]
ATGAAAAAAATTGATTATTTGATGCGCTTACGCAAGTGTACAACGATTGACACGCTTGAACGCGTTATCGAGAAGAACAA
GTATCAGTTGTCTAGCGATGAGCTGGAAATGTTTTATTCTGCCGCCGATCATCGTTTAGCCGAGCTAACGATGAACAAGA
TTTACGACAAGGTCCCTACCGCCGTTTGGAAATACGTCCGCTAA

Antitoxin


Download         Length: 61 bp

>AT175263 NZ_CP062465:c513310-513250 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References