Detailed information of TA system TA175256

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprG3-SprA2AS/-
• Location: 2666808..2667071
• Replicon: chromosome
• Accession: NZ_CP062439
• Organism: Staphylococcus aureus strain NAS_AN_285

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF743_RS13265
• Protein ID: WP_001802298.1
• Coordinates: 2666808..2666912 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2666907..2667071 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF743_RS13235	2662192..2662974	+	783	WP_000908176.1	ABC transporter ATP-binding protein	-
IF743_RS13240	2663042..2663899	+	858	WP_000370924.1	HAD family hydrolase	-
IF743_RS13250	2664604..2664696	-	93	WP_001790138.1	hypothetical protein	-
IF743_RS13255	2664985..2666121	+	1137	WP_000115564.1	SAP domain-containing protein	-
IF743_RS13260	2666164..2666647	+	484	Protein_2578	recombinase family protein	-
IF743_RS13265	2666808..2666912	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2666907..2667071	-	165	-	-	Antitoxin
IF743_RS13275	2667412..2668503	-	1092	WP_000495671.1	lytic regulatory protein	-
IF743_RS13280	2668769..2669749	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
IF743_RS13285	2669751..2670071	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF743_RS13290	2670223..2670888	+	666	WP_001024094.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T175256 WP_001802298.1 NZ_CP062439:2666808-2666912 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T175256 NZ_CP081858:c3766731-3766318 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGTCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin

Nucleotide

• Length: 165 bp

>AT175256 NZ_CP062439:c2667071-2666907 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin