Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2401801..2402318 Replicon chromosome
Accession NZ_CP062439
Organism Staphylococcus aureus strain NAS_AN_285

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag IF743_RS11880 Protein ID WP_000113262.1
Coordinates 2402052..2402318 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag IF743_RS11875 Protein ID WP_000584502.1
Coordinates 2401801..2402052 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF743_RS11845 (2397502) 2397502..2398221 + 720 WP_000479576.1 amino acid ABC transporter permease -
IF743_RS11850 (2398218) 2398218..2398949 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
IF743_RS11855 (2399046) 2399046..2400296 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
IF743_RS11860 (2400551) 2400551..2400910 + 360 WP_000819847.1 DUF4467 domain-containing protein -
IF743_RS11865 (2400929) 2400929..2401528 + 600 WP_000162813.1 DsbA family protein -
IF743_RS11870 (2401535) 2401535..2401636 + 102 WP_001791744.1 hypothetical protein -
IF743_RS11875 (2401801) 2401801..2402052 + 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF743_RS11880 (2402052) 2402052..2402318 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
IF743_RS11885 (2402353) 2402353..2402424 + 72 Protein_2312 hypothetical protein -
IF743_RS11890 (2402613) 2402613..2404163 + 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
IF743_RS11895 (2404349) 2404349..2404816 + 468 WP_000153344.1 SRPBCC domain-containing protein -
IF743_RS11900 (2404900) 2404900..2405082 + 183 WP_000230294.1 hypothetical protein -
IF743_RS11905 (2405299) 2405299..2406123 + 825 WP_000572040.1 formate/nitrite transporter family protein -
IF743_RS11910 (2406356) 2406356..2406892 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T175255 WP_000113262.1 NZ_CP062439:2402052-2402318 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T175255 NZ_CP081858:c2609697-2609594 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT175255 WP_000584502.1 NZ_CP062439:2401801-2402052 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT175255 NZ_CP081858:2609592-2609735 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References