Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2344947..2345470 Replicon chromosome
Accession NZ_CP062439
Organism Staphylococcus aureus strain NAS_AN_285

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag IF743_RS11605 Protein ID WP_000074048.1
Coordinates 2345204..2345470 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag IF743_RS11600 Protein ID WP_000587616.1
Coordinates 2344947..2345204 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF743_RS11580 (2340027) 2340027..2341220 + 1194 WP_000675401.1 MFS transporter -
IF743_RS11585 (2341444) 2341444..2342193 - 750 WP_000072444.1 CPBP family lipoprotein N-acylation protein LnsB -
IF743_RS11590 (2342388) 2342388..2343965 + 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
IF743_RS11595 (2344133) 2344133..2344588 - 456 WP_000732082.1 DUF1307 domain-containing protein -
IF743_RS11600 (2344947) 2344947..2345204 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF743_RS11605 (2345204) 2345204..2345470 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
IF743_RS11610 (2345825) 2345825..2346901 + 1077 WP_001076671.1 M42 family metallopeptidase -
IF743_RS11615 (2347149) 2347149..2347811 + 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
IF743_RS11620 (2347804) 2347804..2348580 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
IF743_RS11625 (2348976) 2348976..2350163 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T175252 WP_000074048.1 NZ_CP062439:2345204-2345470 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T175252 NZ_CP081858:508325-508633 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGGTTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT175252 WP_000587616.1 NZ_CP062439:2344947-2345204 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT175252 NZ_CP081858:508083-508322 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
ATGTCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCTGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTGCTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References