Detailed information of TA system TA175239

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2577758..2578036
• Replicon: chromosome
• Accession: NZ_CP062421
• Organism: Staphylococcus aureus strain NAS_AN_003

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF693_RS12670
• Protein ID: WP_001802298.1
• Coordinates: 2577758..2577862 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2577858..2578036 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF693_RS12655	2574555..2575337	+	783	WP_000908189.1	ABC transporter ATP-binding protein	-
IF693_RS12660	2575405..2576262	+	858	WP_000370928.1	HAD family hydrolase	-
IF693_RS12665	2576920..2577078	-	159	WP_001792784.1	hypothetical protein	-
IF693_RS12670	2577758..2577862	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2577858..2578036	-	179	-	-	Antitoxin
IF693_RS12680	2578304..2579395	-	1092	WP_000495681.1	hypothetical protein	-
IF693_RS12685	2579661..2580641	-	981	WP_000019743.1	CDF family zinc efflux transporter CzrB	-
IF693_RS12690	2580643..2580963	-	321	WP_000003755.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF693_RS12695	2581115..2581780	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T175239 WP_001802298.1 NZ_CP062421:2577758-2577862 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T175239 NZ_CP081834:9388-10281 [Vagococcus lutrae]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAGTGATAATTTGGAAGAATTGGTTCAAGGTAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGAAAAACCAGTTTGCGATCAGCAATTT
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGTG
AAACTTTATGAAAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATAAAGGGTATAATTTGGTGATTGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTCATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGGTATGAA
ACTATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGCTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GCTTAGAAACGCCTTCCATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAATATCAGGGAAAGAAATTCAA
CCGACTTTGGAGAGAATAGAGCAAAAAATGGTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
AATGGAAAGCTTGCAGCCACCTACACCAGCAATACCCAAAACACCTAAACTTCCAGGGGTTCTGTTGCAAAGTTTTAAAT
CTACTATCAAATAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT175239 NZ_CP062421:c2578036-2577858 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin