Detailed information of TA system TA175234

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2268147..2268670
• Replicon: chromosome
• Accession: NZ_CP062421
• Organism: Staphylococcus aureus strain NAS_AN_003

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: IF693_RS11085
• Protein ID: WP_000074046.1
• Coordinates: 2268404..2268670 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A2K4AGF2
• Locus tag: IF693_RS11080
• Protein ID: WP_000587615.1
• Coordinates: 2268147..2268404 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF693_RS11060 (2263242)	2263242..2264435	+	1194	WP_000675403.1	MFS transporter	-
IF693_RS11065 (2264659)	2264659..2265408	-	750	WP_000019956.1	CPBP family lipoprotein N-acylation protein LnsB	-
IF693_RS11070 (2265598)	2265598..2267175	+	1578	WP_240128211.1	FMN-binding glutamate synthase family protein	-
IF693_RS11075 (2267325)	2267325..2267789	-	465	WP_000736689.1	DUF1307 domain-containing protein	-
IF693_RS11080 (2268147)	2268147..2268404	+	258	WP_000587615.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IF693_RS11085 (2268404)	2268404..2268670	+	267	WP_000074046.1	Txe/YoeB family addiction module toxin	Toxin
IF693_RS11090 (2268983)	2268983..2270059	+	1077	WP_001076667.1	M42 family metallopeptidase	-
IF693_RS11095 (2270307)	2270307..2270969	+	663	WP_000923528.1	ATP-binding cassette domain-containing protein	-
IF693_RS11100 (2270962)	2270962..2271735	+	774	WP_000072148.1	iron export ABC transporter permease subunit FetB	-
IF693_RS11105 (2272087)	2272087..2273271	+	1185	WP_000115415.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-67)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10658.27 Da
• Isoelectric Point: 10.1384

>T175234 WP_000074046.1 NZ_CP062421:2268404-2268670 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKPFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T175234 NZ_CP081828:20703-21173 [Klebsiella quasipneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACAGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGACAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATAGCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9746.68 Da
• Isoelectric Point: 4.1111

>AT175234 WP_000587615.1 NZ_CP062421:2268147-2268404 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLDDWKSIQETIYLESTGTMDKVRDREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT175234 NZ_CP081828:20263-20706 [Klebsiella quasipneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATAAATGAAGGTCTGGACGGGAAGGTGGCGAACCGGATAACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCAACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGTATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAGGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAAACGGGAGCCTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A2K4AGF2