Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2319216..2319733 Replicon chromosome
Accession NZ_CP062420
Organism Staphylococcus aureus strain NAS_AN_016

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag IF696_RS11390 Protein ID WP_000113262.1
Coordinates 2319467..2319733 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag IF696_RS11385 Protein ID WP_000584499.1
Coordinates 2319216..2319467 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF696_RS11360 (2315060) 2315060..2316379 + 1320 WP_001808146.1 ISL3-like element IS1181 family transposase -
IF696_RS11365 (2316458) 2316458..2317708 - 1251 WP_001012223.1 FemA/FemB family glycyltransferase FmhA -
IF696_RS11370 (2317963) 2317963..2318325 + 363 WP_000819843.1 DUF4467 domain-containing protein -
IF696_RS11375 (2318344) 2318344..2318943 + 600 WP_000162813.1 DsbA family protein -
IF696_RS11380 (2318950) 2318950..2319051 + 102 WP_031774922.1 hypothetical protein -
IF696_RS11385 (2319216) 2319216..2319467 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF696_RS11390 (2319467) 2319467..2319733 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
IF696_RS11395 (2319768) 2319768..2319845 + 78 Protein_2215 hypothetical protein -
IF696_RS11400 (2320029) 2320029..2321579 + 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
IF696_RS11405 (2321765) 2321765..2322232 + 468 WP_000153344.1 SRPBCC domain-containing protein -
IF696_RS11410 (2322319) 2322319..2322501 + 183 WP_000079142.1 hypothetical protein -
IF696_RS11415 (2322718) 2322718..2323542 + 825 WP_000572040.1 formate/nitrite transporter family protein -
IF696_RS11420 (2323775) 2323775..2324311 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2315060..2316379 1319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T175222 WP_000113262.1 NZ_CP062420:2319467-2319733 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T175222 NZ_CP081821:c153046-152897 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT175222 WP_000584499.1 NZ_CP062420:2319216-2319467 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT175222 NZ_CP081821:153091-153150 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References