Detailed information of TA system TA175209

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2588371..2588633
• Replicon: chromosome
• Accession: NZ_CP062419
• Organism: Staphylococcus aureus strain NAS_AN_023

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF697_RS12695
• Protein ID: WP_001802298.1
• Coordinates: 2588371..2588475 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2588470..2588633 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF697_RS12675	2585168..2585950	+	783	WP_000908189.1	ABC transporter ATP-binding protein	-
IF697_RS12680	2586018..2586875	+	858	WP_240122450.1	HAD family hydrolase	-
IF697_RS12685	2587533..2587691	-	159	WP_001792784.1	hypothetical protein	-
IF697_RS12690	2587684..2587854	-	171	WP_001792292.1	transposase	-
IF697_RS12695	2588371..2588475	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2588470..2588633	-	164	-	-	Antitoxin
IF697_RS12705	2588974..2590065	-	1092	WP_000495681.1	hypothetical protein	-
IF697_RS12710	2590331..2591311	-	981	WP_000019743.1	CDF family zinc efflux transporter CzrB	-
IF697_RS12715	2591313..2591633	-	321	WP_000003755.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF697_RS12720	2591785..2592450	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T175209 WP_001802298.1 NZ_CP062419:2588371-2588475 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T175209 NZ_CP081818:c7737-7321 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCGTCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTAGCCGGGACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCACGCCATCGCGGCGGGCGCCATCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAAATAA

Antitoxin

Nucleotide

• Length: 164 bp

>AT175209 NZ_CP062419:c2588633-2588470 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin