Detailed information of TA system TA175206

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2307047..2307231
• Replicon: chromosome
• Accession: NZ_CP062419
• Organism: Staphylococcus aureus strain NAS_AN_023

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: IF697_RS11220
• Protein ID: WP_000482650.1
• Coordinates: 2307047..2307154 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2307171..2307231 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF697_RS11195	2302419..2302892	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
IF697_RS11200	2303015..2304226	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IF697_RS11205	2304408..2305067	-	660	WP_000831298.1	membrane protein	-
IF697_RS11210	2305127..2306269	-	1143	WP_001176863.1	glycerate kinase	-
IF697_RS11215	2306527..2306913	+	387	WP_000779358.1	flippase GtxA	-
IF697_RS11220	2307047..2307154	+	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2307171..2307231	-	61	-	-	Antitoxin
IF697_RS11225	2307802..2309565	+	1764	WP_001064820.1	ABC transporter ATP-binding protein	-
IF697_RS11230	2309590..2311323	+	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
IF697_RS11235	2311554..2311721	+	168	WP_001792506.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T175206 WP_000482650.1 NZ_CP062419:2307047-2307154 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T175206 NZ_CP081816:3320302-3320712 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT175206 NZ_CP062419:c2307231-2307171 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin