Detailed information of TA system TA175205

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2275531..2276054
• Replicon: chromosome
• Accession: NZ_CP062419
• Organism: Staphylococcus aureus strain NAS_AN_023

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: T1YCD0
• Locus tag: IF697_RS11080
• Protein ID: WP_000074043.1
• Coordinates: 2275788..2276054 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: IF697_RS11075
• Protein ID: WP_000587618.1
• Coordinates: 2275531..2275788 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF697_RS11060 (2272027)	2272027..2272776	-	750	WP_000072441.1	CPBP family lipoprotein N-acylation protein LnsB	-
IF697_RS11065 (2272971)	2272971..2274548	+	1578	WP_240122441.1	FMN-binding glutamate synthase family protein	-
IF697_RS11070 (2274716)	2274716..2275171	-	456	WP_000732082.1	DUF1307 domain-containing protein	-
IF697_RS11075 (2275531)	2275531..2275788	+	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IF697_RS11080 (2275788)	2275788..2276054	+	267	WP_000074043.1	Txe/YoeB family addiction module toxin	Toxin
IF697_RS11085 (2276410)	2276410..2277486	+	1077	WP_001076665.1	M42 family metallopeptidase	-
IF697_RS11090 (2277734)	2277734..2278396	+	663	WP_000923524.1	ATP-binding cassette domain-containing protein	-
IF697_RS11095 (2278389)	2278389..2279165	+	777	WP_000072147.1	iron export ABC transporter permease subunit FetB	-
IF697_RS11100 (2279561)	2279561..2280748	+	1188	WP_000026187.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10657.45 Da
• Isoelectric Point: 10.3584

>T175205 WP_000074043.1 NZ_CP062419:2275788-2276054 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T175205 NZ_CP081816:2815452-2815799 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT175205 WP_000587618.1 NZ_CP062419:2275531-2275788 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT175205 NZ_CP081816:2815799-2816098 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Structures

Toxin

• AlphaFold DB: T1YCD0

Antitoxin

• AlphaFold DB: T1YBB2