Detailed information of TA system TA175201

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 183492..183672
• Replicon: chromosome
• Accession: NZ_CP062419
• Organism: Staphylococcus aureus strain NAS_AN_023

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: IF697_RS01140
• Protein ID: WP_001801861.1
• Coordinates: 183577..183672 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	183492..183549 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF697_RS01110	179843..180961	+	1119	WP_000072558.1	restriction endonuclease subunit S	-
IF697_RS01115	181609..182025	+	417	WP_020978241.1	DUF1433 domain-containing protein	-
IF697_RS01120	182331..182609	+	279	WP_001798632.1	DUF1433 domain-containing protein	-
IF697_RS01125	182631..183005	+	375	WP_000695818.1	DUF1433 domain-containing protein	-
IF697_RS01130	183193..183375	+	183	Protein_187	transposase	-
IF697_RS01135	183353..183454	-	102	WP_001791232.1	hypothetical protein	-
-	183492..183549	+	58	-	-	Antitoxin
IF697_RS01140	183577..183672	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
IF697_RS01145	184123..184569	+	447	WP_000747802.1	DUF1433 domain-containing protein	-
IF697_RS01150	185254..185637	+	384	WP_000070811.1	hypothetical protein	-
IF697_RS01155	185648..185824	+	177	WP_000375476.1	hypothetical protein	-
IF697_RS01160	186124..186752	+	629	Protein_193	ImmA/IrrE family metallo-endopeptidase	-
IF697_RS01165	186950..187522	-	573	WP_000414206.1	hypothetical protein	-
IF697_RS01170	187623..187964	-	342	WP_000627547.1	DUF3969 family protein	-
IF697_RS01175	188005..188631	-	627	WP_000669021.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / hlgA / lukD	154597..220281	65684

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T175201 WP_001801861.1 NZ_CP062419:c183672-183577 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T175201 NZ_CP081816:1187554-1187772 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT175201 NZ_CP062419:183492-183549 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin