Detailed information of TA system TA175191

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2292499..2292683
• Replicon: chromosome
• Accession: NZ_CP062418
• Organism: Staphylococcus aureus strain NAS_AN_136

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: IF715_RS11230
• Protein ID: WP_000482647.1
• Coordinates: 2292499..2292606 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2292623..2292683 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF715_RS11205	2287871..2288344	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
IF715_RS11210	2288467..2289678	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IF715_RS11215	2289860..2290519	-	660	WP_000831298.1	membrane protein	-
IF715_RS11220	2290579..2291721	-	1143	WP_001176863.1	glycerate kinase	-
IF715_RS11225	2291979..2292365	+	387	WP_000779360.1	flippase GtxA	-
IF715_RS11230	2292499..2292606	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2292623..2292683	-	61	-	-	Antitoxin
IF715_RS11235	2293310..2295073	+	1764	WP_001064814.1	ABC transporter ATP-binding protein	-
IF715_RS11240	2295098..2296831	+	1734	WP_000486489.1	ABC transporter ATP-binding protein	-
IF715_RS11245	2297062..2297229	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T175191 WP_000482647.1 NZ_CP062418:2292499-2292606 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T175191 NZ_CP081813:2693709-2693816 [Shigella flexneri]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT175191 NZ_CP062418:c2292683-2292623 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin