Detailed information of TA system TA175186

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 19378..19716
• Replicon: chromosome
• Accession: NZ_CP062418
• Organism: Staphylococcus aureus strain NAS_AN_136

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: IF715_RS00100
• Protein ID: WP_072353918.1
• Coordinates: 19378..19554 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	19542..19716 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF715_RS00080	14545..18327	+	3783	WP_240088607.1	phage tail spike protein	-
IF715_RS00085	18320..18472	+	153	WP_001000058.1	hypothetical protein	-
IF715_RS00090	18518..18805	+	288	WP_001262620.1	hypothetical protein	-
IF715_RS00095	18861..19235	+	375	WP_000340977.1	hypothetical protein	-
IF715_RS00100	19378..19554	+	177	WP_072353918.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	19542..19716	-	175	-	-	Antitoxin
IF715_RS00110	19766..20020	+	255	WP_000611512.1	phage holin	-
IF715_RS00115	20032..20787	+	756	WP_000861038.1	CHAP domain-containing protein	-
IF715_RS00120	20977..21468	+	492	WP_000920041.1	staphylokinase	-
IF715_RS00125	22120..22455	+	336	Protein_24	SH3 domain-containing protein	-
IF715_RS00130	22964..23314	+	351	WP_000702262.1	complement inhibitor SCIN-A	-
IF715_RS00135	23367..23627	-	261	WP_001791826.1	hypothetical protein	-
IF715_RS00140	23938..24117	-	180	WP_000669789.1	hypothetical protein	-
IF715_RS00145	24489..24686	-	198	WP_000239610.1	phospholipase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / scn	52..23314	23262

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.43 Da
• Isoelectric Point: 9.9479

>T175186 WP_072353918.1 NZ_CP062418:19378-19554 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T175186 NZ_CP081813:2020026-2020129 [Shigella flexneri]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 175 bp

>AT175186 NZ_CP062418:c19716-19542 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Antitoxin