Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 2730499..2730913 | Replicon | chromosome |
| Accession | NZ_CP062417 | ||
| Organism | Staphylococcus aureus strain NAS_AN_143 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | IF718_RS13475 | Protein ID | WP_001065046.1 |
| Coordinates | 2730499..2730750 (+) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | IF718_RS13480 | Protein ID | WP_000028424.1 |
| Coordinates | 2730740..2730913 (+) | Length | 58 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IF718_RS13435 (2726156) | 2726156..2727076 | + | 921 | WP_000138475.1 | recombinase RecT | - |
| IF718_RS13440 (2727157) | 2727157..2727774 | + | 618 | WP_072353921.1 | MBL fold metallo-hydrolase | - |
| IF718_RS13445 (2727775) | 2727775..2728245 | + | 471 | WP_000934762.1 | single-stranded DNA-binding protein | - |
| IF718_RS13450 (2728275) | 2728275..2729168 | + | 894 | WP_000148327.1 | DnaD domain-containing protein | - |
| IF718_RS13455 (2729175) | 2729175..2729393 | + | 219 | WP_000338527.1 | hypothetical protein | - |
| IF718_RS13460 (2729402) | 2729402..2729857 | + | 456 | WP_000401965.1 | RusA family crossover junction endodeoxyribonuclease | - |
| IF718_RS13465 (2729870) | 2729870..2730238 | + | 369 | WP_000101270.1 | SA1788 family PVL leukocidin-associated protein | - |
| IF718_RS13470 (2730242) | 2730242..2730484 | + | 243 | WP_000131381.1 | phi PVL orf 51-like protein | - |
| IF718_RS13475 (2730499) | 2730499..2730750 | + | 252 | WP_001065046.1 | DUF1024 family protein | Toxin |
| IF718_RS13480 (2730740) | 2730740..2730913 | + | 174 | WP_000028424.1 | hypothetical protein | Antitoxin |
| IF718_RS13485 (2731002) | 2731002..2731196 | + | 195 | WP_231119680.1 | hypothetical protein | - |
| IF718_RS13490 (2731197) | 2731197..2731358 | + | 162 | WP_000889682.1 | hypothetical protein | - |
| IF718_RS13495 (2731373) | 2731373..2731906 | + | 534 | WP_001061838.1 | dUTPase | - |
| IF718_RS13500 (2731943) | 2731943..2732188 | + | 246 | WP_001282074.1 | hypothetical protein | - |
| IF718_RS13505 (2732185) | 2732185..2732391 | + | 207 | WP_000195803.1 | DUF1381 domain-containing protein | - |
| IF718_RS13510 (2732388) | 2732388..2732774 | + | 387 | WP_000592201.1 | hypothetical protein | - |
| IF718_RS13515 (2732771) | 2732771..2732920 | + | 150 | WP_000595305.1 | transcriptional activator RinB | - |
| IF718_RS13520 (2733079) | 2733079..2733729 | + | 651 | WP_001005262.1 | hypothetical protein | - |
| IF718_RS13525 (2733729) | 2733729..2733929 | + | 201 | WP_000265041.1 | DUF1514 family protein | - |
| IF718_RS13530 (2733952) | 2733952..2734422 | + | 471 | WP_000282758.1 | hypothetical protein | - |
| IF718_RS13535 (2734537) | 2734537..2734989 | + | 453 | WP_000406191.1 | nucleoside triphosphate pyrophosphohydrolase family protein | - |
| IF718_RS13540 (2735005) | 2735005..2735349 | + | 345 | WP_000817289.1 | HNH endonuclease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | groEL / hlb | 2705217..2735944 | 30727 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9377.26 Da Isoelectric Point: 3.7128
>T175185 WP_001065046.1 NZ_CP062417:2730499-2730750 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY
Download Length: 252 bp
>T175185 NZ_CP081813:1332441-1332839 [Shigella flexneri]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA
Antitoxin
Download Length: 58 a.a. Molecular weight: 6468.29 Da Isoelectric Point: 4.2484
>AT175185 WP_000028424.1 NZ_CP062417:2730740-2730913 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
Download Length: 174 bp
>AT175185 NZ_CP081813:1332214-1332441 [Shigella flexneri]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|