Detailed information of TA system TA175179

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2583045..2583307
• Replicon: chromosome
• Accession: NZ_CP062417
• Organism: Staphylococcus aureus strain NAS_AN_143

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF718_RS12670
• Protein ID: WP_001802298.1
• Coordinates: 2583045..2583149 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2583144..2583307 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF718_RS12655	2579842..2580624	+	783	WP_000908182.1	ABC transporter ATP-binding protein	-
IF718_RS12660	2580692..2581549	+	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
IF718_RS12665	2582207..2582365	-	159	WP_001792784.1	hypothetical protein	-
IF718_RS12670	2583045..2583149	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2583144..2583307	-	164	-	-	Antitoxin
IF718_RS12680	2583582..2584673	-	1092	WP_000495669.1	hypothetical protein	-
IF718_RS12685	2584939..2585916	-	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
IF718_RS12690	2585918..2586238	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF718_RS12695	2586390..2587055	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T175179 WP_001802298.1 NZ_CP062417:2583045-2583149 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T175179 NZ_CP081791:c3828963-3828565 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Nucleotide

• Length: 164 bp

>AT175179 NZ_CP062417:c2583307-2583144 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin