Detailed information of TA system TA175176

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2294969..2295153
• Replicon: chromosome
• Accession: NZ_CP062417
• Organism: Staphylococcus aureus strain NAS_AN_143

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: IF718_RS11160
• Protein ID: WP_000482652.1
• Coordinates: 2294969..2295076 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2295093..2295153 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF718_RS11135	2290331..2290804	+	474	WP_000456486.1	GyrI-like domain-containing protein	-
IF718_RS11140	2290927..2292138	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IF718_RS11145	2292320..2292979	-	660	WP_000831298.1	membrane protein	-
IF718_RS11150	2293039..2294181	-	1143	WP_001176863.1	glycerate kinase	-
IF718_RS11155	2294449..2294835	+	387	WP_000779360.1	flippase GtxA	-
IF718_RS11160	2294969..2295076	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2295093..2295153	-	61	-	-	Antitoxin
IF718_RS11165	2295779..2297542	+	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
IF718_RS11170	2297567..2299300	+	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
IF718_RS11175	2299567..2299698	+	132	WP_223197975.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T175176 WP_000482652.1 NZ_CP062417:2294969-2295076 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T175176 NZ_CP081791:2803454-2803561 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT175176 NZ_CP062417:c2295153-2295093 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin