Detailed information of TA system TA175168

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 19379..19717
• Replicon: chromosome
• Accession: NZ_CP062417
• Organism: Staphylococcus aureus strain NAS_AN_143

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: IF718_RS00100
• Protein ID: WP_072353918.1
• Coordinates: 19379..19555 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	19543..19717 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF718_RS00080	14546..18328	+	3783	WP_000582132.1	phage tail spike protein	-
IF718_RS00085	18321..18473	+	153	WP_001000058.1	hypothetical protein	-
IF718_RS00090	18519..18806	+	288	WP_001262620.1	hypothetical protein	-
IF718_RS00095	18862..19236	+	375	WP_000340977.1	hypothetical protein	-
IF718_RS00100	19379..19555	+	177	WP_072353918.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	19543..19717	-	175	-	-	Antitoxin
IF718_RS00110	19767..20021	+	255	WP_000611512.1	phage holin	-
IF718_RS00115	20033..20788	+	756	WP_000861038.1	CHAP domain-containing protein	-
IF718_RS00120	20979..21470	+	492	WP_000920038.1	staphylokinase	-
IF718_RS00125	22121..22456	+	336	Protein_24	SH3 domain-containing protein	-
IF718_RS00130	22967..23317	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
IF718_RS00135	23370..23630	-	261	WP_001791826.1	hypothetical protein	-
IF718_RS00140	23941..24120	-	180	WP_000669791.1	hypothetical protein	-
IF718_RS00145	24492..24689	-	198	WP_000239610.1	phospholipase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / scn / hlb / map	52..26511	26459

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.43 Da
• Isoelectric Point: 9.9479

>T175168 WP_072353918.1 NZ_CP062417:19379-19555 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T175168 NZ_CP081791:870346-871659 [Escherichia coli]
ATGAAAATGCAGACGCTAACAGTGGCGATGAATGGTGAGGTCGTAGGAACACTGTACCGAGATAACAAAGGGGCCATGTC
ATTTCAGTATGCCCCGGAGTGGATCTCGGAACCAGGTTCACGCGCCATTTCCATGTCACTGCCTTTGGGTCATGGCAGGA
TCACAGGAAGTGAAGTCTTCAATTTCTTTAGCAACCTCCTACCCGACTCAGAGGCAATTATTGCCAGGATGCAGGCTAGG
TTCAGAGTTGAGACAACACATCCATTTGATTTGCTGGCGAGTGTTGGCCGGGATTGTGTTGGAGCTATCCAGCTCTATTC
CCCCGATGCGGACATCCCAACTGTAATGGAGACGCTTGCAGAGCCTCTGGATGAAGCTCAGATTGAGCAACTGCTTGAAG
GCTACCAGGAAGCGCCCCTTGGGATGGCAGAGGATGCTGATTTTCGGATCTCGATTGCCGGAGCCCAAGAGAAAACTGCA
CTGCTTTGGTATCAGGACCGCTGGCAACGCCCCCTGGGCAGCACCCCAACAAGCCATATTTTTAAGCTACCCATTGGTAA
GATTGTTCAAAATAACATCGATCTCAGTGAGAGTTGTGAGAATGAATGGCTCTGTTTGCGCATTGCAAAGGCCTTCGGTT
TTGACGTCGCCAATGCGGACCTAGCAACGTTCGGCAAGAAGAAGGTGCTTGTCGTTCAGCGTTTTGACCGGCGCTGGTCT
AAATCCGGCGAATGGCTTCTACGATTGCCCCAAGAAGACTTCTGCCAAGCTCTTGGGATCGCTCCTGCGCTCAAATACGA
GTCACATGGAGGGCCAGGTATTGCTGACGCAATGAAGTTGTTGTTGGGGTCCAGACTTGCGGCTAAGGATAGAGAGCAAT
TTTTCAAGTCGCAGATCCTATTCTGGATGTTGGCCGCGATTGATGGGCACGGGAAGAACTTCTCCATCTTCATTGAGCCT
GCATCGTCATTTAGGATGACCCCCCTCTACGATGTCATGTCTGCTTTTCCTATCTTCAAAAGCGGGGGAATTGCTGCTCA
AAAGGCAAAGATGGGGATGGCGCTCCAAGGCAAAAACCGCCAATACCATTTTGCGATGATCCAGCCTCGTCATTTTATCA
GTACCGCCGCCCATGTCGGGTTCCCACAAGATACCGCCGCTCAACTTATGTTCGACATGGCTACCAAGACAGAGGAGGTG
GTTGCCACAGTAGCGGCTGAGCTGCCAGCCGGTTTCCCAGAGCACATCAGTAGCGCCATCTTCGAGGGGCTGTCCAGCCA
GGCGGCTAAGATCTTGAAGGGAGTAGCCAAATGA

Antitoxin

Nucleotide

• Length: 175 bp

>AT175168 NZ_CP062417:c19717-19543 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Antitoxin