Detailed information of TA system TA175162

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2592123..2592385
• Replicon: chromosome
• Accession: NZ_CP062416
• Organism: Staphylococcus aureus strain NAS_AN_149

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF719_RS12700
• Protein ID: WP_001802298.1
• Coordinates: 2592123..2592227 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2592222..2592385 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF719_RS12680	2588920..2589702	+	783	WP_000908189.1	ABC transporter ATP-binding protein	-
IF719_RS12685	2589770..2590627	+	858	WP_000370928.1	HAD family hydrolase	-
IF719_RS12690	2591285..2591443	-	159	WP_001792784.1	hypothetical protein	-
IF719_RS12695	2591436..2591606	-	171	WP_001792292.1	transposase	-
IF719_RS12700	2592123..2592227	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2592222..2592385	-	164	-	-	Antitoxin
IF719_RS12710	2592726..2593817	-	1092	WP_000495681.1	hypothetical protein	-
IF719_RS12715	2594083..2595063	-	981	WP_240113281.1	CDF family zinc efflux transporter CzrB	-
IF719_RS12720	2595065..2595385	-	321	WP_000003755.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF719_RS12725	2595537..2596202	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T175162 WP_001802298.1 NZ_CP062416:2592123-2592227 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T175162 NZ_CP081791:187027-187134 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 164 bp

>AT175162 NZ_CP062416:c2592385-2592222 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin